leky-latky/lipidy/lipolyza-mk

• Metabolism of fatty acids is initiated on the outer mitochondrial membrane
• Catalysed by acyl-CoA synthetase
• Required partly to enable the transport of the fatty acids into the mitochondrial matrix
• Fatty acid forms an acyl-adenylate
• While still tightly bound to the enzyme, acyl-adenylate is converted to acyl-CoA
• Medium-chain acyl-CoA
• Long-chain acyl-CoA and AMP

• Acyl-CoA
• Can then be transported into the mitochondria
• Using different pathways
• Depending on the fatty acid chain length [1]