leky-latky/lipidy/lipolyza-mk
- Metabolism of fatty acids is initiated on the outer mitochondrial membrane
- Catalysed by acyl-CoA synthetase
- Required partly to enable the transport of the fatty acids into the mitochondrial matrix
- Fatty acid forms an acyl-adenylate
- While still tightly bound to the enzyme, acyl-adenylate is converted to acyl-CoA
- Medium-chain acyl-CoA
- Long-chain acyl-CoA and AMP
- Acyl-CoA
- Can then be transported into the mitochondria
- Using different pathways
- Depending on the fatty acid chain length [1]