leky-latky/APOA2-gen/funkce

Adipogenesis

• 265 APOA2 region
• Possibility of allele-specific binding of the transcription factor CEBPA [CCAAT/enhancer binding protein (C/EBP), alpha]
• Involved in adipogenesis [5]

Apolipoprotein A-II

• In humans is encoded by the APOA2 gene
• Second most abundant protein of the high density lipoprotein particles
• In plasma as a monomer, homodimer, or heterodimer with apolipoprotein D

Satiety signal

• APOA2 acts as a satiety signal
• As described for APOA4 in other studies
• Significant associations between the APOA2 -265T>C SNP and food intake in Framingham and in GOLDN [5]

Stabilizac eHDL

• May stabilize HDL (high density lipoprotein) structure
• By its association with lipids, and affect the HDL metabolism [2]