CD4 subpopulace
CD4/CD45RA (32 - 49 %) a CD4/CD45RO (45 -75 %)
Pacientka s diabetem - v.s. s podílem autoimunity
- CD4/CD45RA 8 % (32 - 49) L (naivní, imunosupresivní)
- CD4/CD45RO 89 % (45 -75) H (paměťové, prozánětlivé)
Hledání v odborné literatuře
Význam
- The CD45RA antigen
- First expressed by T-lineage cells relatively late during their intrathymic maturation
- Continues to be expressed by most T cells in the immunologically naive neonate
- CD4+CD45RA+ cells
- Immunoregulatory functions
- Suppression of immune responses
- Directly
- Via the induction of suppressor activity by CD8+ cells
- CD45RA-/RO+ cells
- With increasing age and antigenic exposure
- Become more prevalent in the circulation
- Comprise the majority of cells in tissues
- Functions uniquely performed
- Proliferative responses to "memory" recall antigens
- Ability to provide help for antibody production
- "memory" cells that derive from "naive" or "virgin" CD45RA+/RO- precursors via an activation-dependent postthymic differentiation pathway.
- Altered frequencies of CD45RA+ and CD45RO+ T cells
- Observed in a variety of different clinical conditions with altered immune function
- pubmed.ncbi.nlm.nih.gov/1532395/
DM1
- T helper lymphocytes (CD4+) play a key role in the etiopathogenesis of type 1 diabetes
- Naive (CD4+CD45RA+)
- Memory cells (CD4+CDRO+)
- Lymphocytes coexpressing both studied phenotypes (CD4+CD45RA+CD45RO+) in subjects at risk of type 1 diabetes
- First degree relatives of IDDM patients with autoantibodies
- Higher percentages of lymphocytes coexpressing CD45RA and CD45RO antigens in peripheral blood
- In first degree relatives with "pro-diabetogenic" DRB1*0401 allele
- With impairment of first phase of insulin release (FPIR) in IVGTT
- CD4+CD45RA+/CD4+CD45RO+ cells ratio was significantly lower
- In subjects with protective DQB1*0602 alelle and/or higher FPIR levels
- Alterations of CD45RA and CD45RO antigens expression on T helper cells in prediabetics
- Suggest the significant role of naive or/and memory CD4+ T cell subsets in the pathogenesis of diabetes type 1.
- CD4+CD45RA+/CD4+CD45RO+ ratio could serve as surrogate marker of diabetes type 1 risk development
- Estimation of the efficacy of the preventive procedures in subjects at high risk of IDDM
- pubmed.ncbi.nlm.nih.gov/11450149/
- Simultaneous coexpression of both CD45RA and CD45RO (CD45RA+RO+) on CD4 and CD8 lymphocytes
- In patients with recent-onset IDDM was higher than in control subjects (P < 0.001)
- Proportion of CD4 lymphocytes expressing CD45RA alone (CD45RA+RO-)
- Was similar in these groups
- Percentage of CD8 lymphocytes that were CD45RA+RO-
- Was significantly higher in the patients with recent-onset IDDM (P < 0.05)
- In long-standing IDDM
- Total CD45RA+ expression on CD4 and CD8 lymphocytes was reduced
- Compared with control subjects (P < 0.05)
- As a result of a tendency of CD45RA+RO- and CD45RA+RO+ subsets to be lower
- Increase in total naive (CD45RA+) lymphocytes and in coexpression of naive (CD45RA) and memory (CD45RO) markers on CD4 and CD8 lymphocytes subsets
- In recent-onset IDDM
- Abnormal regulation of T-cell activation and maturation is important in the pathogenesis of the disease
