MUDr. Dana Maňasková


Vyhledávání na medicinman.cz
 

Kardioprotektivni latky

Brief Ischemia Episodes Create Cardioprotective Effect

  • Ischemia experienced in brief episodes
    • Could protect the heart by preparing it for a heart attack, according to early findings from an animal study by researchers at the University of Cincinnati
  • Preconditioning activated a protective pathway called Janus kinase (JAK) to signal transducers and activators of transcription (STAT). The JAK-STAT pathway could offer a therapy against the damage of a heart attack.
  • www.dicardiology.com/content/brief-ischemia-episodes-create-cardioprotective-effect

Daucus carota Linn

  • Known to have cardioprotective potential
  • Daucus carota
  • White-flowering herb belongs to Apiaceae plant family
  • Generally recognized as wild carrot
  • Native to temperate regions of Southeast Asia and Europe
  • Roots and seeds
  • Daucosol, xanthophylls, carotene, sesquiterpenoids, and daucoside
  • Muralidharan et al47 studied the cardioprotective potential of D carota Linn’s aqueous extract in isoproterenol-induced MI in rats
  • Cardioprotection by determining the activity of cardiac enzymes like transaminases, lipid peroxidases, cardiac protein, and lactate dehydrogenase (LDH).

Nerium oleander (NO) Linn

Amaranthus viridis

Ginkgo biloba

  • Known to have cardioprotective potential
  • Leaves and seeds of G biloba have been reported to have cardioprotective effect.
  • Panda in his study administered Ocimum sanctum and G biloba extract in isoproterenol-induced myocardial necrosis rats.
    • Increase in serum enzymes of isoproterenol-induced myocardial necrosis rats compared with serum enzymes of normal rats
    • Isoproterenol at a dose of 85 mg/kg body weight was administered through subcutaneous route
    • Serum enzymes level was reduced significantly on the 29th and 30th days of therapy.
  • Ocimum sanctum (100 mg/kg body weight) and G biloba (50 mg/kg body weight)
    • Showed significant cardioprotection as compared to combined administration of O sanctum (50 mg/kg body weight) and G biloba (100 mg/kg body weight)
  • www.ncbi.nlm.nih.gov/pmc/articles/PMC6537262/

Terminalia arjuna

Tinospora cordifolia

Hydrocotyle asiatica Linn

Mucuna pruriens

Cichorium intybus

  • Known to have cardioprotective potential
  • Cichorium intybus from genus Cichorium belongs to Asteraceae plant family
  • Cichory plant contains a number of phytocompounds of medicinal importance
    • Flavonoids, coumarins, vitamins, inulin, volatile compounds, esculin, and lactones
  • Cichory contains volatile oils, phenolics, flavonoids, alkaloids, glycosides, saponins, tannins, fatty acids, emodine, triterpenoids, and anthracene
  • Nayeemunnisa et al90 studied the C intybus for its cardioprotective potential against aging myocardium in albino rats
    • By administering the plant powder for 30 days
    • Aging caused an increase in taurine and glutathione level while decreasing the catalase activity in heart
    • Treatment with cichory plant ameliorated the oxidative damage and aging-induced injury of the heart.
  • www.ncbi.nlm.nih.gov/pmc/articles/PMC6537262/

Elaiotsipoura

Enalapril

  • Initiated 1 month after completion of high-dose chemotherapy
  • Continued for 1 year in a heterogenous cohort of patients with cancer with evidence of acute myocardial injury
    • Raised cardiac troponin I concentration (>70 ng/L) at the time of high-dose chemotherapy
  • Effect of enalapril was impressive
    • 43% of patients in the control group, but none in the enalapril group, reaching the primary cardiotoxicity outcome of an absolute reduction in LVEF >10% points to a level <50%
  • The remarkable results of the intervention and the attractive personalized approach to select patients for therapy provided a rationale for further studies
    • For potentially applying this approach to all patients receiving anthracycline therapy.
  • www.jacc.org/doi/10.1016/j.jaccao.2022.01.101

Angiotensin receptor and neprilysin inhibition with sacubitril-valsartan

  • Provides more complete neurohormonal inhibition
  • Associated with reduced mortality and morbidity compared with standard treatment in patients with heart failure with reduced ejection fraction
  • Preventive cardioprotective effect of sacubitril-valsartan during (neo)adjuvant therapy in patients scheduled to receive anthracycline-containing therapy is currently being tested in a randomized, placebo-controlled, multicenter trial of patients with early breast cancer
    • (PRADA II [Prevention of Cardiac Dysfunction During Breast Cancer Therapy]; NCT03760588)
  • www.jacc.org/doi/10.1016/j.jaccao.2022.01.101

Exercise training

  • Systematic review and meta-analysis of randomized trials of exercise training in adult patients with cancer
    • Exercise therapy was associated with improved cardiorespiratory fitness
      • (+2.80 mL O2 · kg-1 · min-1 vs 0.02 mL O2 · kg-1 · min-1; P < 0.001)
  • www.jacc.org/doi/10.1016/j.jaccao.2022.01.101

Dendrobium officinale Kimura et Migo


Dexrazoxane

  • Iron-chelating agent
  • Documented cardioprotective effects
  • Leading to cytosolic iron sequestration
  • Inhibition of doxorubicin-topoisomerase complex formation
    • Leading to reduced apoptosis, ferroptosis, and necroptosis, may also play a role
  • Approved by the U.S. Food and Drug Administration in 1995
  • In 2014 was designated an orphan drug for “prevention of cardiomyopathy for children and adolescents 0 through 16 years of age treated with anthracyclines.”
  • Concerns related to a potential for reduced anticancer effect and increased risk for secondary malignancies
    • European Medicines Agency in 2011 to restrict its use to patients with advanced metastatic breast cancer receiving high cumulative doses of doxorubicin or epirubicin.
  • 2017, the European Medicines Agency overturned its prior decision
    • Allowed dexrazoxane also to be given to children and adolescents who are likely to be treated with high cumulative doses of anthracyclines (>300 mg/m2 doxorubicin).
  • Cardioprotective effect of dexrazoxane has been evaluated in several randomized controlled trials in children, adolescents, and adults
    • Bolus infusion immediately prior to doxorubicin
      • Associated with less reduction in LV fractional shortening and wall thickness than with doxorubicin alone
  • Meta-analysis that included 10 studies of 1,619 patients
    • Dexrazoxane was associated with a significant reduction in the pooled estimate of the incidence of heart failure (risk ratio [RR]: 0.29; 95% CI: 0.20-0.41)
  • Recent systematic review and meta-analysis that incorporated 2,177 patients from 7 prospective clinical trials and 2 retrospective studies of patients with breast cancer
    • Dexrazoxane significantly reduced the risk for clinical heart failure (RR: 0.19; 95% CI: 0.09-0.40) and cardiac events (RR: 0.36; 95% CI: 0.27-0.49)
    • Rate of a partial or complete oncological response, overall survival, and progression-free survival appeared to be unaffected in patients with early or metastatic breast cancer receiving anthracyclines with or without trastuzumab
    • Evidence in early-stage breast cancer is limited
      • Meta-analysis <10% of the cohort had early-stage breast cancer
  • None of the included randomized trials were considered to be at low risk for bias across bias domains
  • Further randomized trials are warranted before systematic implementation of dexrazoxane for primary prevention of cardiotoxicity can be recommended in this setting.
  • Dexrazoxane has also been suggested as a secondary cardioprotective therapy during anthracycline treatment in patients with preexisting ventricular dysfunction
    • One consecutive case series, dexrazoxane was used off label concomitantly with anthracyclines.
    • During chemotherapy, mean LV ejection fraction (LVEF) decreased from 39% to 34%, but no patient developed symptomatic heart failure
  • www.jacc.org/doi/10.1016/j.jaccao.2022.01.101

Prevence anthracycline-associated cardiotoxicity

  • Substitution with alternative anticancer drugs
  • Reduction of anthracycline dose
  • Slow infusion rather than bolus injection
  • Liposomal doxorubicin
  • A meta-analysis of randomized controlled trials
    • Bolus administration of doxorubicin was associated with a higher rate of clinical and subclinical cardiotoxicity (OR: 4.13; 95% CI: 1.75-9.72)
    • Liposomal formulation was associated with a reduced rate (OR: 0.18; 95% CI: 0.08-0.38)
  • Epirubicin
    • Associated with lower risk for clinical cardiotoxicity than doxorubicin
      • (OR: 0.39; 95% CI: 0.20-0.78)
  • Other meta-analyses also are in support of liposomal vs nonliposomal doxorubicin
    • Benefit vs epirubicin is less clear
  • www.jacc.org/doi/10.1016/j.jaccao.2022.01.101

Polygonum cuspidatum Sieb. et Zucc. Root extract

Cyclovirobuxine D

  • Contains cyclovirobuxine-D, steroidal alkaloid, artemetin, 4',5-dihydroxy-3,3',7-tetra methoxy flavones, (-)-(Z)-buxenone, (-)-(E)-buxenone.113 -Yu et al studied the Buxus microphylla to investigate its cardioprotective potential
    • Rats against left coronary artery occlusion-induced heart failure
    • Rats were given cyclovirobuxine D, derivative of B microphylla for a period of 4 weeks
    • Cardiac functions, hemodynamics, microcirculation, histology, and mortality assessments were recorded
    • Cyclovirobuxine D is useful for the management of cardiac failure due to occlusion of left coronary artery
      • Leading to the development of new therapeutic agents for the treatment of cardiac failure.
  • www.ncbi.nlm.nih.gov/pmc/articles/PMC6537262/

Withanolides

  • Withania somnifera -(300 mg/kg body weight) purified extract (withanolide 1.5%)
  • Male Wistar rats
    • Doxorubicin (10 mg/kg body weight) to induce necrosis and apoptosis in cardiac tissues.
    • Doxorubicin administration in rats causes elevation in
      • protein carbonyl levels,
      • Catalase activity,
      • Malondialdehyde due to oxidative stress
    • Total antioxidant capacity and superoxide dismutase activity were exhausted in heart tissues
    • Study concluded that W somnifera possess efficient cardioprotective potential against doxorubicin-induced cardiotoxicity
  • www.ncbi.nlm.nih.gov/pmc/articles/PMC6537262/

Silymarin

  • Experimental rats against ischemia-reperfusion–induced MI
    • 2 different doses (100, 250, and 500 mg/kg body weight) of silymarin for 7 days
    • Occlusion of left anterior descending coronary artery was performed after 1 week of silymarin treatment for 30 minutes
    • Then reperfused for 4 hours
    • Control group rats showed significant cardiac necrosis as evident from elevated serum enzyme levels (SGPT, SGOT, and LDH).
    • Silylmarin administration resulted in the restoration of endogenous antioxidant enzyme activities, suppressed neutrophil infiltration, and reduced infarct area in test group rats as compared to control group rats.
  • www.ncbi.nlm.nih.gov/pmc/articles/PMC6537262/

Flax lignin

  • Linum usitatissimum seeds extract (flax lignan concentrate) was studied for cardioprotective activity against isoprenaline-induced myocardial necrosis in rats
    • Male Wistar rats (200-230 g) were divided into 3 groups as control group, isoprenaline group, and test (flax lignin treated) group
    • Flax lignin concentrate (500 mg/kg body weight) for 8 days
    • Isoprenaline was given to rats except control rats at a dose of 5.25 and 8.5 mg/kg body weight subcutaneously during 9th and 10th day of therapy
    • Isoprenaline-induced cardiotoxicity was evident from the elevated cardiac enzymes level
    • Flax lignin concentrate restored the activities of cardiac enzymes by lowering the serum enzymes level in cardiotoxicity-induced rats
      • Flax lignin concentrate has cardioprotective effect on isoprenaline-induced cardiotoxicity
  • www.ncbi.nlm.nih.gov/pmc/articles/PMC6537262/

Against isoproterenol-induced cardiotoxity

Fountain tree, African tulip tree, pichkari or nandi flame Spathodea campanulata

  • Bignoniaceae
  • Bark
  • Ethanol extract
  • Saponin, flavonoids, steroid, alkaloids, glycoside, tannin, phenol, phlobatanin, terpenoids, and anthraquinone
  • Antimalarial, anti-HIV, hypoglycemic, cardioprotective 9

Garlic Allium sativum

  • Liliaceae
  • Bulb Garlic oil
  • Alkaloids, flavonoids, tannins, saponins, and cardiac glycosides
  • Antimicrobial, antihyperlipidemic, and cardioprotective 10

Hairy fig Ficus hispida

  • Moraceae
  • Leaves
  • Methanol Alkaloids, terpenes, saponins, glycosides, mucilage, gums, flavonoids, phenols, sterols, amino acids, ß-amyrine acetate, protein, carbohydrates, n-triacontanol, lupeol acetate, ß-sitosterol, gluanol, and ß-amyrin
  • Cardioprotective, antipyretic, hepatoprotective, anti-inflammatory 11

Kerala ginseng, ginseng of Kani tribes Trichopus zeylanicus

  • Trichpodaceae
  • Leaves
  • Ethanol
  • Alkaloids, glycosides, flavonoids, steroids, tannins, steroids, terpenoids
  • Cardioprotective, adoptogenic, aphrodisiac 12

Gokhru, kharkhask, caltrop Tribulus terrestris

  • Zygophyllaceae
  • Fruit
  • Aqueous
  • Flavonol, flavonoids, alkaloids, glycosides, and steroidal saponins Cardioprotective, antilithiatic, diuretic, hypouricemic, anti-inflammatory, aphrodisiac 13,14

Baladur, billar, bhilavan Semecarpus anacardium

  • Anacardiaceae
  • Dried nuts
  • Ethanol
  • Bhilwanols, phenolic compounds, biflavonoids, sterols, glycosides, ursuhenol, anacardoside, semecarpetin, nallaflavanone, jeediflavanone, semecarpuflavanone
  • Cardioprotective, antioxidant, anticancer, antidiabetic 15

Kalmegh Andrographis paniculata

  • Acanthaceae
  • Leaves
  • Methanol
  • Andrographolide, diterpenoids, flavonoids, quinic acid, xanthones, noriridoids, and andrographidoids A, B, C, D, and E Cardioprotective, gastroprotective, antioxidant 16

Zafran, Saffron Crocus sativus

  • Iridaceae
  • Flowers
  • Aqueous Carotenoid compounds, crocetin, crocin, safranal, glucoside picrocrocin, anthocyanins, delphinidin, petunidin Cardioprotective, hypnotic, anxiolytic, anticancer 17

Tulsi Ocimum sanctum

  • Lamiaceae
  • Seeds
  • Hydroalcohol Alkaloids, saponins, tannin, steroid, flavonoids, terpenoid
  • Cardioprotective, antioxidant, hypolipidemic, hypoglycemic 18

Basil, Saint-Joseph’s-wort Ocimum basilicum

  • Lamiaceae
  • Aerial parts
  • Ethanol
  • Flavonoids, phenolic compounds
  • Antibacterial, antifungal, antioxidant, and cardioprotective 19

Moringa, drumstick tree Moringa oleifera

  • Moringaceae
  • Leaves
  • Hydroalcohol
  • Tannins, saponins, alkaloids, terpenes, carbohydrates, flavonoids, and cardiac glycosides Anticancer, anti-inflammatory, antipyretic, and cardioprotective 20,21

Bottle gourd Lagenaria siceraria

  • Cucurbitaceae
  • Fruit Juice
  • Sterols, flavonoids, terpenoids, and saponin
  • Antioxidant, antihyperlipidemic, and cardioprotective 22

Picrorhiza, kutki, katuka Picrorhiza kurroa

  • Scrofulariaceae
  • Rhizome
  • Ethanol
  • Sterols, glycosides, phenolic compounds, cucurbitacins (triterpenoids), and iridoid glycosides
  • Antioxidant, anti-inflammatory, and cardioprotective 23

Ban tulasi, raan tulas Croton sparsiflorus

Against isoprenaline hydrochloride–induced cardiotoxicity

Neem tree, Indian lilac Azadirachta indica

  • Meliaceae
  • Aqueous
  • Leaves
  • Reducing sugar, tannins, flavonoids, steroids, terpenoids, glycosides, and alkaloids
  • Cardioprotective, chemopreventive, antiplasmodial, anti-inflammatory 25

Gander Coleus forskohlii

  • Lamiaceae
  • Roots
  • Ethanol
  • Forskolin hydrochloride, demethylcryptojaponol, ?-amyrin, betulic acid, ?-cedrol and ß-sitosterol, diterpene glycosides, and diterpenoids forskolin
  • Antihypertensive, antithrombotic, antiobesity, and cardioprotective 26

Kokum, red mango tree Garcinia indica

  • Clusiaceae
  • Fruit
  • Aqueous
  • Garcinol, isoxanthochymol, xanthochymol, hydroxycitric acid, phenolic acids, flavonoids, benzophenones, isogarcinol, anthocyanins, and tannins
  • Cardioprotective, antibacterial, hepatoprotective, antioxidant 27

Against ischemia-reperfusion–induced cardiotoxicity

Hawthorn Crataegus oxyacantha

  • Rosaceae
  • Berries
  • Ethanol
  • Flavonoids, oligomeric procyanidins, triterpenes, phenolic acids, fatty acids, and sterols
  • Anti-inflammatory, antiapoptotic, and cardioprotective 28

Lemon guava, Guava Psidium guajava

  • Myrtaceae
  • Leaves
  • Aqueous
  • Phenolic, carotenoid, flavonoid, terpenoid, and triterpene.
  • Cardioprotective, antispasmodic, antidiabetic 29

Gotu kola, Brahmi Hydrocotyle asiatica

  • Umbelliferae
  • Whole plant
  • Alcohol
  • Alkaloids, flavonoids, and glycosides Cardioprotective, antipsoriatic, neuroprotective 30

Maqui berry Aristotelia chilensis

  • Elaeocarpaceae
  • Fruits
  • Methanol
  • Phenolic compounds, anthocyanidins, flavonoids, delphinidin, cyanidin, gallate, gallocatechin gallate, quercetin, rutin, myricetin, and catechin action Cardioprotective, antioxidant, analgesic, anti-inflammatory 31

Arjuna or arjun tree Terminalia arjuna

Against doxorubicin-induced cardiomyopathy

Bottle brush Callistemon lanceolatus

  • Myrtaceae
  • Leaves
  • Ethanol
  • Phenolic compounds, carbohydrates, saponins, alkaloids, flavonoids, glycosides, phytosterols, and tannins
  • Anti-inflammatory, antioxidant, and cardioprotective 33

Stone breaker, Black katnip Phyllanthus niruri

  • Phyllanthaceae
  • Whole plant
  • Aqueous
  • Flavonoids, terpenoids, alkaloids, lignans, tannins, polyphenols, coumarins, and saponins
  • Cardioprotective, anticancer, antimicrobial, hypolipidemic, antihepatotoxic 34

Turmeric Curcuma longa

  • Zingiberaceae
  • Rhizome
  • Ethanol
  • Curcumin, ar-turmerone, ß-sesquiphellandrene, curcumenol, sesquiterpenes, and phenolic constituents
  • Cardioprotective, anti-inflammatory, antioxidant 35

Shershir Tribulus macropterus

  • Zygophyllaceae
  • Aerial parts
  • Methanol
  • Flavonoids, saponins, alkaloids, glycosides, and flavonol
  • Cytotoxic and cardioprotective 36

Olive Olea europaea Oleaceae

  • Aerial parts
  • Methanol
  • Flavonoids, iridoids, secoiridoids, flavanones, benzoic acid derivatives, and triterpenes
  • Antidiabetic, anticancer, antimicrobial, and cardioprotective 36

Athel tree, Athel pine, and saltceda Tamarix aphylla

  • Tamaricaceae
  • Aerial parts
  • Methanol
  • Alkaloids, tannins, glycosides, phenolic compounds, and saponins.
  • Antidiabetic, anticholinsterase, antioxidant, and cardioprotective 36

Sorrel Hibiscus sabdariffa

  • Malvaceae Petals
  • Aqueous
  • Tannins, saponnins, phenols, glycosides, alkaloids, and flavonoids
  • Antihypertensive, antioxidant, and cardioprotective 37

Malta fungus Cynomorium coccineum

  • Cynomoriaceae
  • Aerial parts
  • Methanol
  • Alkaloids, glycosides, anthraquinones, flavonoids, tannins, saponins, and terpenoids
  • Antioxidant, antihypertensive, and cardioprotective 36

Assyrian plum Cordia myxa

  • Boraginaceae
  • Fruit
  • Methanol
  • Flavonoids, saponins, and tannin
  • Anti-inflammatory, analgesic, and cardioprotective 36

Calligonum comosum Polygonaceae

  • Aerial parts
  • Methanol
  • Flavonoids, anthraquinones, and dehydrodicatechin
  • Cytotoxic, anticancer, and cardioprotective 36

Camellia sinensis

  • Theaceae
  • Leaves
  • Aqueous
  • Tannins, flavonoids, steroids, and flavonoids
  • Antioxidant, antiobesity, and cardioprotective 38

Withania somnifera

  • Solanaceae
  • Leaves and roots
  • Herbal tablet
  • Alkaloids, steroids, glycosides, hentriacontane, dulcitol, withaniol, withananine, withananinine, pseudo-withanine, tannins, and flavonoids
  • Anti-inflammaory, analgesic, immunomodulant, antirhematic, and cardioprotective 39

Ficus racemosa

  • Moraceae
  • Bark
  • Acetone
  • Flavonoids, triterpenoids, alkaloids, tannins, kaempferol and coumarin, glycoside
  • Antioxidant, hepatoprotective, and cardioprotective 40

Onion Allium cepa

Against cigarette smoke–exposed rats

Sesbania grandiflora

  • Fabaceae
  • Leaves
  • Aqueous suspension
  • Alkaloids, flavonoids, glycosides, tannin, anthraquinone, steroid, pholobatannins, and terpenoids
  • Antibacterial, anxiolytic, and cardioprotective 42
  • www.ncbi.nlm.nih.gov/pmc/articles/PMC6537262/

Against glucose-induced oxidative stress in H9C2 cardiomyocytes

Syzygium cumini

  • Myrtaceae Seeds
  • Methanol
  • Anthocyanins, ellagic acid, glucoside, kaemferol isoquercetin, alkaloids, myrecetin, glycosides, and jambosine
  • Antidiabetic, antioxidant, and cardioprotective 43
  • www.ncbi.nlm.nih.gov/pmc/articles/PMC6537262/

Against Naja sputatrix (Javan spitting cobra) venom

Velvet bean, Cowhage Mucuna pruriens

  • Fabaceae
  • Seeds
  • Aqueous
  • Alkaloids, sterols, saponins, alkylamines, 6-methoxyharman, mucunain, mucunadine, and mucunine
  • Cardioprotective, antidepressant, neuroprotective 44

Allium sativum

  • Liliaceae Bulb Allicin, sulfur compounds 93

Anacardium occidentale

  • Anacardiaceae Stem bark Flavonoids, carotenoids 94

Buxus microphylla

  • Buxaceae Leaves Cyclovirobuxine D 95

Antiaris toxicaria

  • Moraceae Bark Cardiac glycosides 96

Asparagus racemosus

  • Asparagaceae Roots Saponin-shatavarins 1-1V 97

Ganoderma lucidum

  • Ganodermataceae Fruit Triterpenes 98

Leptadenia pyrotechnica

  • Asclepiadaceae Aerial parts Triterpenoids 98,99

Digitalis purpurea

  • Scrophulariaceae Leaves Cardiac glycosides 100

Tinospora cordifolia

  • Menispermaceae Whole plant Bitter constituents including tinosporon, tinosporol, tinosporic acid, palmarin, chasmanthin, and columbin; alkaloidal constituents including berberine 101

Crataeva nurvala

  • Capparidaceae Stem bark Pentacyclic triterpene, lupeol and its ester 102

Raphanus sativus

  • Cruciferae Fruit Caffeic acid 103

Crocus sativus

  • Iridaceae Flowers Crocin 104

Glycyrrhiza glabra

  • Leguminaceae Roots Glycyrrhizic acid 105

Garcinia kola

  • Guttiferae Seeds Kolaviron 106

Garcinia mangostana

  • Guttiferae Fruit ? Mangostin 107

Morus alba

  • Moraceae Leaves Morin 108

Aegle marmelos

  • Rutaceae Fruit Marmesin 109

Catharanthus roseus

  • Apocynaceae Leaves Vincristine 110

Moringa oleifera

  • Moringaceae Leaves Vincosamide 111

Zingiber officinale


Mangifera indica L. leaf extract

  • Alleviates doxorubicin induced cardiac stress
  • Journal of intercultural ethnopharmacology 6 (3), 284, 2017, Laxit Bhatt,Viraj Joshi,

Vrikshamla

  • Int J Ayu Pharm Chem, November 10th 2020.Sruthi Mohan et al.,

Punica granatum extract

  • Cardioprotective potential in isoproterenol-induced myocardial infarction in Wistar rats
  • Journal of pharmacology & pharmacotherapeutics 1 (1), 32, 2010 Mahalaxmi Mohan,et al.,

Citrus medica “Otroj”

  • Attenuates oxidative stress and cardiac dysrhythmia in isoproterenol-induced cardiomyopathy in rats
  • Reasearch gate 5 (11), 4269-4283, 2013, Mohammed A Al-Yahya, et al,,

Grape polyphenol extract

  • Cardioprotective effect of against doxorubicin induced cardiotoxicity
  • Nature research, Rep. 2020. Shynggys Sergazy et al.,

Emblica officinalis (amla)

  • Protective effect on isoproterenol-induced cardiotoxicity in rats
  • Toxicology and Health. 2012 Jun. Shreesh Ojha et al.,

Terminalia chebula

  • Protective effect of against experimental myocardial injury induced by isoproterenol
  • NISCAIR-CSIR, 2004 Feb. S Suchalatha et al.,

Terminalia bellirica (Roxb.)

  • Investigation on protective effect against drugs induced cardiotoxicity in wistar albino rats
  • J Ethnopharmacol. 2020. Rahul Chaudhary et al.,

Cissampelos pareira root extract

  • On isoproterenol-induced cardiac dysfunction,
  • J Nat Med. 2013 Jan, Bhulan Kumar Singh et al.,

Boerhavia diffusa L.

  • Polyphenol rich ethanolic extract mitigates angiotensin II induced cardiac hypertrophy and fibrosis in rats
  • Biomed Pharmacother, 2017 Mar., Prathapan A et al.,

Mucuna Pruriens

  • Myocardial Protective Impact on Isoproterenol Prompted Myocardial,
  • Published 2018, Rakam Gopi Krishna and Raja Sundararajan,

Terminalia arjuna bark

  • Cardioprotective action of the aqueous extract against toxicity induced by doxorubicin,
  • Phytomedicine, 2017, Sarah Bishop et al.

Desmodium gangeticum root extract

  • Attenuates isoproterenol-induced cardiac hypertrophic growth in rats
  • Journal of Pharmacy & Pharmacognosy Research 2(5):129-137 October 2014, Divya Hitler et al.,

Gokshura Phala (Tribulus terrestris Linn.) AND GAMBHARI PHALA (Gmelina arborea Roxb.)

  • For Hrudya Karma (Cardioprotective Activity)-An Experimental Study,
  • 2020.Arpitha C Rao, A Comparative Evaluation of Efficacy of

Hemidesmus indicus

  • Cardioprotective effect of the root extract of against doxorubicin Induced oxidative stress in mice
  • Der Pharmacia Lettre 5(1), January 2013 Mahsa Zarei et al.,

Achyranthes aspera (Linn)

  • Cardiac stimulant activity of the saponin of , Indian J Med Res.,1972 Mar. S S Gupta et al.,

Tinospora cordifolia

  • Cardioprotective activity of alcoholic extract of in ischemia-reperfusion induced myocardial infarction in rats, Biol Pharm Bull. 2005 Dec. Pragada Rajeswara Rao et al.,

Moringa oleifera leaf extract

  • Prevents isoproterenol-induced myocardial damage in rats: evidence for an antioxidant, antiperoxidative, and cardioprotective intervention,
  • J Med Food. 2009 Feb. Mukesh Nandave et al.,

Carissa crandas L

  • Effect of on saline modulated cardiac hypertropy in rats,
  • Journal of Pharmacy Research, 2010. G.Rabbini et al.,

Solanum xanthocarpum

  • Cardioprotective Activity of in Isoproterenol Induced Myocardial Infarction in Rats
  • IJPPR, 25 May 2016. Victor Arokia doss.D et al.

Ziziphus jujuba fruit extract

  • Protective effects of long-term administration on cardiovascular responses in L-NAME hypertensive rats
  • Avicenna J Phytomed. Mar-Apr 2018. Reza Mohebbati et al.,

Garcinia pedunculata

  • Cardioprotective activity of fruit of on isoprenaline- induced myocardial infarction in rat,
  • Bangladesh Journal of Pharmacology, 2016. Ravi Mundugaru et al.

Glycyrrhiza glabra

  • Protects from myocardial ischemia-reperfusion injury by improving hemodynamic, biochemical, histopathological, and ventricular function,
  • Exp Toxicol Pathol, 2013 Jan.Shreesh Ojha et al.,

Solanum indicum ssp. distichum extract

  • Is effective against L-NAME-induced hypertension in rats,
  • Fundamental and Clinical Pharmacology, 1 Dec 2008. A.Bahgat et al.,

Asparagus racemosus

  • Evaluation of Cardioprotective activity against Doxorubicin induced cardiotoxicity in albino rats: an experimental study,
  • IJBCP, 2003.Pinki Vishwakarma et al.,

Citrullus Colocynthis

  • Evaluation of Cardioprotective Potential of Hydroalcoholic Peel Extract of Research Square,
  • December 11th 2020.Ashira Manzoor et al.,

Pongamia pinnata

  • Cardioprotective effect of hydro-alcoholic leaf extract against Isoproterenol induced myocardial infarction in wistar rats,
  • Int J Med Pharmaceut Sci, 2012.Behera Saiprasanna et al.,

Argyreia speciosa (Burm. f) Boj.

  • Cardioprotective effect extracts against Isoproterenol-induced myocardial infarction in rats,
  • Oriental Pharmacy and Experimental medicine, 2010.Shalin Thakker et al.,

Cassia fistula bark

  • Evaluation of methanolic extract for cardioprotective activity,
  • IJRAP, 2010.NA Khatib et al.,

Saccharum officinarum peels

  • Antiobesity and cardioprotective impact of extract on experimentally induced obese male rats
  • Research Gate, October 2020.Nabil Soliman et al.,

Leptadenia reticulata

  • Antioxidant and cardioprotective effect of against adriamycin-induced myocardial oxidative damage in rat experiments,
  • Planta Medica 73 (09), 2007. AS Wakade et al.,
  • Cardioprotective activity of various Herb’s - Research Update, Vol. 7 No. 1 (2022): JAN-FEB / Review Article , Bharati S. Muddannavar Post Graduate Scholar, Dept. of P.G. Studies in Dravyaguna, Govt. Ayurveda Medical College, Bengaluru, Karnataka, India. Anand Katti Associate Professor, Dept. of Samhita Siddhantha, Government Ayurveda Medical College, Bengaluru, Karnataka, India. 2Associate Professor, Dept. of Samhita Siddhantha, Government Ayurveda Medical College, Bengaluru, Karnataka, India.


Tamoxifen lepší než inhibitory aromatáz

  • Antiestrogen therapy, including tamoxifen or aromatase inhibitors, may mimic a postmenopausal state
  • Has not been shown to aggravate cardiovascular disease in patients with breast cancer
  • Neither tamoxifen nor aromatase inhibitors have been shown to increase the risk for cardiovascular disease in comparison with placebo
  • Tamoxifen has been shown to have a favorable effect on the lipid profile
  • In a population-based study of 17,922 patients with breast cancer, aromatase inhibitors were associated with increased risks for heart failure and cardiovascular mortality compared with the use of tamoxifen
  • www.jacc.org/doi/10.1016/j.jaccao.2022.01.101

Thioredoxin


Ursolic acid

O úroveň výše

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