Acacetin

Popis účinků acacetinu

• O-methylated flavone
• A flavonoid with anti-peroxidative and anti-inflammatory properties
• It is used in traditional Chinese medicine
• Recognized as an antiproliferative agent on cancer cell lines
• Inducing apoptosis
• Blocking cell cycle progression in the G1 phase [77]
• Induces cell cycle arrest and apoptosis in a time- and dose-dependent manner
• In several cancer cell lines in vitro [82]
• Acacetin uncoupled photosynthesis light reactions and growth of
• Lolium perenne, Echinochloa crus-galli and Physalis ixocarpa seedlings [77]
• Enhancing electron transport
• Phosphorylating conditions
• Mg(2+)-ATPase [77]
• Anti-aromatase and anti-estrogen properties
• Realigning the ideal balance of hormones in the body after cycling with prohormones and anabolic steroids [79]
• Aromatase tends to trap free testosterone and convert them into estrogen hormones
• Used to treat gynecomastia or “bitch tits”
• Used to reduce increased water retention [79]
• Acacetin Selectively Inhibits Human Atrial Repolarization Potassium Currents
• Prevents Atrial Fibrillation in Dogs [80]
• Prolonged:
• Action potential duration in human atrial myocytes
• Suppressed IKur and the transient outward K+ current [80]
• Atrial effective refractory period
• Corrected QT interval [80]
• Atrium-selective agent
• Effectively prevents AF in anesthetized dogs after intraduodenal administration
• Oral acacetin is a promising atrium-selective agent for the treatment of AF [80]
• Spasmolytic response [81]
• Inhibit TPA-induced the abilities of the adhesion, invasion, and migration by cell-matrix adhesion assay and Boyden chamber assay
• Inhibit phosphorylation of c-Jun N-terminal kinase 1 and 2 (JNK1/2) involved in the down-regulating protein expressions and transcriptions of matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminogen activator (u-PA) induced by TPA
• Strongly inhibited TPA-stimulated the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun
• Dose-dependent inhibition on the binding abilities of NF-kappaB and activator protein-1 (AP-1) by acacetin treatment
• Antimetastatic effects of acacetin on the TPA-induced A549 cells might be by
• Reducing MMP-2 and u-PA expressions through:
• Inhibiting phosphorylation of JNK
• Reducing NF-kappaB
• AP-1 binding activities [83]
• Inhibits the invasion and migration of human prostate cancer DU145 cells
• Inactivation of the p38 MAPK signaling pathway [84]
• Inhibits the invasion and migration of human non-small cell lung cancer A549 cells
• By suppressing the p38? MAPK signaling pathway [85]
• Relief agent for women with menopausal symptoms
• Preventative measure for women at risk for, but without developed hormone sensitive cancers of the breast, uterus and ovaries
• The acacetin exhibited a good activity against isolates MRSA
• Combination of acacetin plus oxacillin or ampicillin
• Synergistic effect
• Time-kill study
• Growth of the tested bacteria was completely attenuated after 2-5 h of treatment with the 1/2 MIC of acacetin
• Regardless of whether it was administered alone or with oxacillin (1/2 MIC) or ampicillin (1/2 MIC)

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