Snižují LDL
Abetalipoproteinemie
- Autosomálně recesivní
- úplnou absencí apoproteinu B -i lipoproteinů, které jej obsahují
- Chylomikrony, LDL a VLDL
- LDL snížena
- V mnoha případech vázne sekrece jaterních VLDL
- Steatóza hepatocytů
- Vázne odsun TAG z enterocytu
- X transport endogenního cholesterolu k periferním buňkám cestou LDL
Abetalipoproteinemie
- Autosomálně recesivní
- úplnou absencí apoproteinu B -i lipoproteinů, které jej obsahují
- Chylomikrony, LDL a VLDL
- LDL snížena
- V mnoha případech vázne sekrece jaterních VLDL
- Steatóza hepatocytů
- Vázne odsun TAG z enterocytu
- X transport endogenního cholesterolu k periferním buňkám cestou LDL
Black Chinese tea - Pu-Erh tea - Pu’er tea
- Show significant decreases in body weight in studies
- Seem to have satisfactory anti-obesity effects [96]
- Significant decrease in body fat [96]
- Significant decrease in waist and hip circumferences [96]
- Decreased the waist-hip ratio significantly [96]
- Kubota et al 2011, Pre-obese male [n?=?36] Black Chinese [Pu-Erh] tea , double blind
- 333 mg before each of 3 daily meal
- 12 wk
- I: extract C: control
- Decrease in BW and BMI
- Sig. effects in reducing the mean WC and visceral fat values
- No adverse effects <0.05 [96]
- Chu et al 2011 , Human with Metsyn [n?=?90] Pu'er tea RCT , double blind
- 4 Cap each time
- Twice per d
- 3 mo
- I: extract C: placebo
- Decrease in
- BMI
- Waist-hip ratio
- Fasting and 2 h postprandial blood glucose
- Serum TC, TG, LDL-chol and apolipoprotein B-100 [96]
Black Chinese tea - Pu-Erh tea - Pu’er tea
- Show significant decreases in body weight in studies
- Seem to have satisfactory anti-obesity effects [96]
- Significant decrease in body fat [96]
- Significant decrease in waist and hip circumferences [96]
- Decreased the waist-hip ratio significantly [96]
- Kubota et al 2011, Pre-obese male [n?=?36] Black Chinese [Pu-Erh] tea , double blind
- 333 mg before each of 3 daily meal
- 12 wk
- I: extract C: control
- Decrease in BW and BMI
- Sig. effects in reducing the mean WC and visceral fat values
- No adverse effects <0.05 [96]
- Chu et al 2011 , Human with Metsyn [n?=?90] Pu'er tea RCT , double blind
- 4 Cap each time
- Twice per d
- 3 mo
- I: extract C: placebo
- Decrease in
- BMI
- Waist-hip ratio
- Fasting and 2 h postprandial blood glucose
- Serum TC, TG, LDL-chol and apolipoprotein B-100 [96]
Familiární hypobetalipoproteinemie
- LDL cholesterolu snížena pod 5. percentil
- Heterozygoté
- Cca 50% hladin LDL [1]
Familiární hypobetalipoproteinemie
- LDL cholesterolu snížena pod 5. percentil
- Heterozygoté
- Cca 50% hladin LDL [1]
Hormony štítné žlázy
- Zvýšení LDL receptorů v játrech
Hormony štítné žlázy
- Zvýšení LDL receptorů v játrech
Irvingia Gabonensis
- West african plants
- Show significant decreases in body weight in studies
- Significant decrease in body fat [96]
- Significant decrease in waist and hip circumferences [96]
- Ngondi et al 2009 [22] Over wt. &/or obese [n?=?102]
- 150 mg /10 wk
- Sig. improvements in BW, body fat, and WC
- Sig. improvements in plasma TC, LDL-chol, BS, CRP, adiponectin and leptin levels 97.9?±?9.1 85.1?±?3.1 <0.01 [96]
Irvingia Gabonensis
- West african plants
- Show significant decreases in body weight in studies
- Significant decrease in body fat [96]
- Significant decrease in waist and hip circumferences [96]
- Ngondi et al 2009 [22] Over wt. &/or obese [n?=?102]
- 150 mg /10 wk
- Sig. improvements in BW, body fat, and WC
- Sig. improvements in plasma TC, LDL-chol, BS, CRP, adiponectin and leptin levels 97.9?±?9.1 85.1?±?3.1 <0.01 [96]
Kůra nadledvin a gonády
- 40% LDL z krve
Kůra nadledvin a gonády
- 40% LDL z krve
LDL receptor
- ER - GA - exocytoza do b.m.
- I mimojaterní tkáně
LDL receptor
- ER - GA - exocytoza do b.m.
- I mimojaterní tkáně
Makrofágy
- Nadbytek LDL
- Nespecificky makrofágy ve stěnách cév
- Scavenger receptory pro oxidací modifikované LDL
- Pěnové buňky, ateroskleróza
Makrofágy
- Nadbytek LDL
- Nespecificky makrofágy ve stěnách cév
- Scavenger receptory pro oxidací modifikované LDL
- Pěnové buňky, ateroskleróza
