Cystein

• Cysteine cannot be administered intravenously due to its toxic effects on the system [1]
• All the amino acids contained in the basic solutions, the only one containing sulphur is L-methionine
• Methionine is metabolized only in the liver [1]
• Malfunctioning or partially functioning liver [1]
• Method for introducing cysteine which can be metabolized as well in organs other than the liver [1]
• L-2-oxothiazolidine-4-carboxylic acid (OTC) [1]
• Administration of the thiazolidine stimulated the formation of glutathione to levels that are about twice those of the controls [1]

N-acetylcystein

• Metabolized to cysteine in the kidney
• Then transported to the liver or peripheral cells
• May not be sufficiently distributed to the requisite tissues of the patient, i.e., the tissue of the lungs. !!! [2]
• Vázne zabezpečení zdroje glutathionu pro pneumocyty v kritickém stavu (ARDS)

L-2-oxothiazolidine-4-carboxylate and glutathione esters

• Při ARDS
• Thiazolidine-4-carboxylate analogs that are converted intracellulary to glutathione can be utilized. [2]
• L-2-oxothiazolidine-4-carboxylate
• 5-oxo-L-prolinase in the presence of adenosine triphosphate produce S-carboxyl cysteine
• Decarboxylated to produce cysteine
• Metabolized to provide glutathione [2]

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