Dýchací řetězec
Dýchací řetězec - MRC
- Mitochondrial respiratory chain (MRC)
- Mediated electron transfer/oxidative phosphorylation
MTCH
- Central role in the regulation of cellular survival and apoptosis [1]
- Intracellular calcium homeostasis
- Various ion channels and transporters [1]
Mitochondrial oxidative capacity
- And capacity for glycolysis
- Important component of the expression of insulin resistance [1]
- Diabetes 2. typu jako porucha spalování a vyčerpaná kapacita střádání energie (vlastní názor na tuto nemoc)
- Maximal oxygen uptake tended to be lower in post obese [1]
- Markers of aerobic capacity of skeletal muscle, may be factors predisposing to obesity [1]
MTCH and biogenesis
- C-Myc role [1]
- ER? and c-MYC physically interact to stabilize the ER?-coactivator complex, thereby permitting other signal transduction pathways to fine-tune estrogen-mediated signaling networks. [1]
MTCH a estrogeny
- E2 or EE stimulated MRC activity via ERs
- Increased generation of mitochondrial superoxide
- + ATP
- Increased oxygen consumption
- Inhibition of apoptosis
- Enhanced distribution of glutasthone in nucleus and mitochondria [1]
- Ovx-induced obesity in mice is associated
- Decrease in oxygen consumption
- Repressed energy expenditure in the absence of E2 [1]
C-myc
- Key transcription factors
- Regulation of enzymes/proteins involved in glycolysis and MRC
- Over-expression of c-myc in liver
Enzymy
- MtDNA-encoded subunits
- Basic catalytic role of electron transport [1]
- MtDNA higher in female rats than in male rats [1]
- NDNA
- Regulatory role [1]
Complex I = NADH-ubiquinone oxidoreductase
- Nuclear DNA (nDNA) and mitochondrial DNA (mtDNA)
Complex II
- NDNA
Coenzym Q
Complex III
- Nuclear DNA (nDNA) and mitochondrial DNA (mtDNA)
Complex IV
- Nuclear DNA (nDNA) and mitochondrial DNA (mtDNA)
Cytochrome-c oxidase
- Lower in subjects with NIDDM [1]
Complex V = Mitochondrial ATP synthase (complex V)
- Nuclear DNA (nDNA) and mitochondrial DNA (mtDNA)
Literatura:
[1] Regulation of Energy Metabolism Pathways by Estrogens and Estrogenic Chemicals and Potential Implications in Obesity Associated with Increased Exposure to Endocrine Disruptors. URL < www.ncbi.nlm.nih.gov/pmc/articles/PMC2747085/?tool=pmcentrez >.
