Glutamin

Udržení Krebsova cyklu

• Dodávka glukózy / glutaminu

Při hypoxii

• The sources of hypoxic citrate synthesis in a glioblastoma cell line that proliferates in profound hypoxia (0.5% O2) [1]
• Glucose uptake and conversion to lactic acid increased in hypoxia. [1]
• Clucose conversion into citrate dramatically declined. [1]
• Glutamine consumption remained constant in hypoxia [1]
• Hypoxic cells were addicted to the use of glutamine in hypoxia as a source of ?-ketoglutarate. [1]
• Glutamine provided the major carbon source for citrate synthesis during hypoxia. [1]
• There was a relative increase in glutamine-dependent citrate production in hypoxia that resulted from carboxylation of ?-ketoglutarate. [1]

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