Symptomy a klinické stavy související s histamínem
Mastocytosis
- Rare disease
- Proliferation of mast cells that produce excess histamine [1]
Multiple sclerosis
- Histamine therapy for treatment of multiple sclerosis is currently being studied
- Different H receptors have been known to have different effects on the treatment of this disease
- H1 and H4 receptors
- Counterproductive in the treatment of MS
- H1 and H4 receptors are thought to increase permeability in the blood-brain barrier
- Thus increasing infiltration of unwanted cells in the central nervous system
- Can cause inflammation, and MS symptom worsening
- H2 and H3 receptors helpful when treating MS patients
- Help with T-cell differentiation
- By helping T cells to differentiate, the T cells will be less likely to attack the body's own cells, and instead attack invaders
Schizophrenia
- Metabolites of histamine
- Increased in the cerebrospinal fluid of people with schizophrenia
- Efficiency of H1 receptor binding sites is decreased
- Atypical antipsychotic medications
- Increasing histamine production [1]
Scombroid poisoning
- histamine production by bacteria in spoiled food
- Particularly fish [1]
Anafylaktický šok
- Snížení tlaku
- Vzniku rozsáhlého otoku a dalším život ohrožujícím účinkům
- Injekcí velké dávky histaminu do krevního řečiště
- Uvolněn po vazbě alergenu na IgE protilátky
- Následuje reakce zprostředkovaná především stimulací H1-receptorů:
- Vazodilataci malých arteriol a kapilár
- Se zvýšením permeability cévní stěny
- S následnou tvorbou edémů
- V plicích dochází k bronchokonstrikci [3]
Erection and sexual function
- Libido loss and erectile failure can occur during treatment with histamine H2 receptor antagonists such as
- Cimetidine,
- Ranitidine
- Risperidone
- Injection of histamine into the corpus cavernosum in men with psychogenic impotence
- Produces full or partial erections in 74% of them
- H2 antagonists may cause sexual difficulties
- By reducing the functional binding of testosterone to its endogenous receptors [1]
Syndrom histaminové intolerance HIT
- Cca 2 - 3 % populace
- častější je u žen středního věku.
- Důsledkem nepoměru mezi přísunem a odbouráváním histaminu v těle
Kognice
- Stimulatory effects upon neurons
- Suppressive protect against the susceptibility to convulsion, drug sensitization, denervation supersensitivity, ischemic lesions and stress
- Controls the mechanisms by which memories and learning are forgotten
Nasal mucous membrane
- Increased vascular permeability
- Fluid to escape from capillaries into the tissues
- Allergic reaction
- A runny nose and watery eyes
- Sneezing
- Due to histamine-associated sensory neural stimulation
- Hyper-secretion
- From glandular tissue
- Nasal congestion
- Due to vascular engorgement associated with vasodilation and increased capillary permeability [1]
Inability to maintain vigilance
- Can occur from the inhibition of histamine biosynthesis or the loss (i.e., degeneration or destruction) of histamine-releasing neurons in the TMN [1]
Senná rýmá
- Při alergické reakci na pyl v nosní sliznici
- Otékáním nosní sliznice a uvolňováním tekutin do nosní dutiny
