Syntéza histamínu
Bacteria v producing histamine
- histidine decarboxylase enzymes
- Unrelated to those found in animals
- Non-infectious form of foodborne disease [1]
- histamine is produced exclusively by decarboxylation of histidine by histidine decarboxylase (HDC) and is catabolized by histamine Nâmethyltransferase (HNMT) or by diamine oxidase 1 (DAO1). These enzymes, together with the four Gâproteinâcoupled receptors H1RâH4R, are ubiquitous in the CNS and mediate histaminergic signalling. In the central nervous system (CNS), histamine regulates motor circuits and neuroâimmune functions, acts as a neuroprotective agent,2 and exerts beneficial effects on microglia under in vitro/in vivo inflammatory conditions.3, 4 In support of this, a condition of impaired histamine production as that occurring in HDC knockout mice decreases M2âlike markers and the neuroprotective role of microglia in vivo.5 Histamine signalling also promotes remyelination,6 protects skeletal muscles against exerciseâinduced fatigue,7 and reduces muscle injury by improving motor performance in Duchenne dystrophic mice.8 Additionally, drugs enhancing histamine transmission, such as histidine or H3R antagonists, exhibit beneficial effects in animal models of Parkinson's disease, attentionâdeficit/hyperactivity disorders, schizophrenia, dementia, and depression2 and are under scrutiny in clinical trials for Alzheimer's disease and multiple sclerosis.
- www.ncbi.nlm.nih.gov/pmc/articles/PMC6711424/
Histidine
- DAO je produkován hlavně v
- Tenkém střevě
- Slinivce břiní
- Pomáhá rozkládat histamin v potravě
Podmínky snytézy histaminu
- Z hisitidu
- Dostupnost volné aminokyseliny (jako histidin)
- Přítomnost mikroorganismů s dekarboxylační aktivitou
- Příznivé podmínky pro dekarboxylaci aminokyselin
- histamine is produced exclusively by decarboxylation of histidine by histidine decarboxylase (HDC)
- www.ncbi.nlm.nih.gov/pmc/articles/PMC6711424/
