Toxicita jódu
Novorozenci se strumou a udušením se
- Neonatal deaths from tracheal obstruction caused by congenital goiters
- Have been reported from such widely scattered locales as
- Buffalo, New York, New York City, Philadelphia, Washington, D.C., Seattle, Tokyo, Japan, and Glasgow, Scotland.
- The mothers of these infants had asthma and were receiving conventional doses of iodides,
- Potassium iodide or as
- Mixtures of bronchodilators and iodides
- Because of these deaths
- Committee on Drugs of the American Academy of Pediatrics
- Reviewed the use of iodides in the therapy of asthma and other chronic pulmonary diseases. [8]
Potassium iodate
Acute oral toxicity
LD50
- Considered based on different studies conducted on rats for the test chemical
- Between 300-2000 mg/kg bw, for acute oral toxicity (2g / kg hmotnosti)
- Can be classified for acute oral toxicity class IV.
echa.europa.eu/cs/registration-dossier/-/registered-dossier/13616/7/3/1
Acute Inhalation Toxicity
- Study need not be conducted
- Exposure to humans via inhalation route is not likely taking into account
- Due to the low vapour pressure of the test chemical
- Reported to be 6.82E-19 Pa
- Exposure to inhalable dust, mist and vapour of the chemical is highly unlikely
- Therefore this study is considered for waiver
echa.europa.eu/cs/registration-dossier/-/registered-dossier/13616/7/3/1
Acute Dermal toxicity
- LD50 was considered based on different studies conducted on rats for the test chemical
- LD50 value is over 2000 mg/kg bw, for acute dermal toxicity
- The given test chemical cannot be classified for acute dermal toxicity.
echa.europa.eu/cs/registration-dossier/-/registered-dossier/13616/7/3/1
