Silymarin

Z rostliny

• Ostropestřec mariánský
• milk thistle
• Silybum marianum

Farmakodynamika silymarinu

• Orally absorbed
• Excreted mainly through bile
• Sulphates
• Conjugates [1]

Složení silymarinu

• 4 flavonolignan isomers:
• Silybin
• The most active and commonly used
• Isosilybin
• Silydianin
• Silychristin [1]

Vlastnosti silymarinu

• Good protection in various toxic models of experimental liver diseases in laboratory animals
• Antioxidative
• Anti-lipid peroxidative
• Antifibrotic
• Anti-inflammatory
• Membrane stabilizing
• Immunomodulatory [1]
• Selectively inhibits leukotriene formation by Kupffer cells [1]
• Liver regenerating [1]

Indikace

• Alcoholic liver diseases
• Liver cirrhosis
• Amanita mushroom poisoning
• Viral hepatitis
• Toxic and drug induced liver diseases
• Diabetic patients
• Does not have antiviral properties against hepatitis virus
• Promotes protein synthesis
• Helps in regenerating liver tissue
• Controls inflammation
• Enhances glucuronidation
• Protects against glutathione depletion [1]
• Hepatobiliary diseases
• Hepatotoxicity due to drugs
• New approach to protect other organs in addition to liver [1]

Výhody

• Good safety profile
• Better patient tolerability
• Effective drug
• Affordable price [1]

Ekonomie

• 180 million US dollars business in Germany alone [1]

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