Strumigeny stimulující degradaci hormonů štítné žlázy
- The monodeiodination of T4 to 3,3',5-triiodothyronine (T3)
- By selenium-containing deiodinases (ID-1, ID-2)
- Key step in the activation of thyroid hormones
- The type 3 deiodinase (ID-3)
- Catalyzes the deactivation of thyroid hormone
- Removes iodine selectively from the tyrosyl ring of T4
- Produce 3,3',5'-triiodothyronine (rT3)
Amiodarone
- Inhibits peripheral conversion of thyroxine to triiodothyronine
- Also interferes with thyroid hormone action.
Carbamazepine
- Induce metabolic degradation of T3 and T4
Phenobarbitone
- Induce metabolic degradation of T3 and T4
Phenytoin
- Induce metabolic degradation of T3 and T4
Rifampin
- Induce metabolic degradation of T3 and T4