MUDr. Dana Maňasková


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Strumigeny stimulující degradaci hormonů štítné žlázy

  • The monodeiodination of T4 to 3,3',5-triiodothyronine (T3)
    • By selenium-containing deiodinases (ID-1, ID-2)
    • Key step in the activation of thyroid hormones
  • The type 3 deiodinase (ID-3)
    • Catalyzes the deactivation of thyroid hormone
    • Removes iodine selectively from the tyrosyl ring of T4
    • Produce 3,3',5'-triiodothyronine (rT3)

Amiodarone

  • Inhibits peripheral conversion of thyroxine to triiodothyronine
  • Also interferes with thyroid hormone action.

Carbamazepine

  • Induce metabolic degradation of T3 and T4

Phenobarbitone

  • Induce metabolic degradation of T3 and T4

Phenytoin

  • Induce metabolic degradation of T3 and T4

Rifampin

  • Induce metabolic degradation of T3 and T4
O úroveň výše

Poslední aktualizace: 3. 6. 2018 0:52:40