Regenerace nervové soustavy
Regenerace nervove soustavy
- Neuroregeneration
- Nerve re-growth
- Regrowth or repair of nervous tissues
Axonální růst
- Central nervous system axons
- Have been proven to regrow in permissive environments [1]
- Human axon growth rates can reach
- 1 mm/day in small nerves
- 5 mm/day in large nerves [1]
Inhibice neuroregenerace
- ECT lacking laminins
Glial scars
- Develops rapidly
- Primary problem to central nervous system axonal regeneration
- Crossing or eliminating the inhibitory lesion site
Glia
- Produce factors inhibitors of remyelination and axon repair
- NOGO
- NI-35 [1]
Zrychlená tvroba glialních jizev
Role in the initiation of scar formation
- Transforming growth factors B-1 and -2
- Interleukins
- Cytokines
Accumulation of reactive astrocytes at the site of injury
- Up regulation of molecules
- Inhibitory for neurite outgrowth
Věk
- Axons lose the potential for growth
- Decrease in GAP 43 expression [1]
- Inhibitory myelin and axonal debris
- Not cleared away as quickly [1]
