Jizvení
Fibrosis
- Like inflammation
- Clinical hallmark of lymphedema. (Kataru et al., 2019)
Lymphedema biopsy samples
- Accumulation of collagen fibers in the reticular and papillary dermis
- Progressive fibrosis
- Luminal obstruction of collecting lymphatics
- Dense accumulation of collagen fibers around capillary lymphatics
- (Mihara et al., 2012)
- Fibrosis, independent of lymphedema
- Associated with decreased lymphatic function in
- Wound healing, radiation, and obesity.
- (Avraham et al., 2002; Clavin et al., 2008; Zampell et al., 2012b)
Transforming growth factor beta-1 (TGF-B1)
- protein growth factor
- Essential role
- TGF-B1 as an important regulator of pathological fibrosis
- (Meng et al., 2016)
- Increased fibroblast collagen deposition,
- Decreased extracellular matrix turnover,
- Modulation of inflammatory response. (Meng et al., 2016)
- Expression of TGF-B1 is increased in clinical lymphedema
- Also plays a role in regulating lymphedema-induced fibrosis. (Sano et al., 2020)
- www.frontiersin.org/articles/10.3389/fphar.2022.828513/full
Operační rány komplikovány infekcí
- Mohou být příčinou lymfatického otoku
Popáleninové trauma
Radioterapie
- Lymfat. syst. silně poškozován
- Dnes místo dobré exenterace axily spíše radioterapie
- Proti chirurgii monohem horší škody tkání
- Dobře provedená miniinvazivní operace je mnohem šetrnější
