- S. pyogenes, the leading cause of necrotizing fasciitis
- Secretes streptolysin S (SLS) to directly activate nociceptor neurons and produce pain during infection.
- Nociceptors, in turn, release the neuropeptide calcitonin gene-related peptide (CGRP) into infected tissues
- Which inhibits the recruitment of neutrophils and opsonophagocytic killing of S. pyogenes.
- Botulinum neurotoxin A and CGRP antagonism
- Block neuron-mediated suppression of host defense
- Preventing and treating S. pyogenes necrotizing infection