nemoci-sympt/VIROLOGIE/chripka/zlepsuje

Hyperoside

• It is the 3-O-galactoside of quercetin.

Isolated from

• Drosera rotundifolia
• Lamiaceae Stachys sp. Prunella vulgaris
• Rumex acetosella
• Cuscuta chinensis seeds
• St John’s wort
• Camptotheca acuminata
• Carpobrotus edulis
• Rheum nobile
• R. rhaponticum
• UV blocker found in the bracts
• Geranium niveum
• Taxillus kaempferi
• Neem Tree
• en.wikipedia.org/wiki/Hyperoside

Proti chřipce

• Molecular docking identified three potential compounds
• Nimbaflavone
• Rutin
• Hyperoside [9]
• Having perfect binding with reported conserved residues (ASP302, SER50) of influenza virus nucleoprotein
• Involved in the binding of drugs [9]
• Further analysis showed Hyperoside
• Universal drug against various influenza strains [9]
• Some chemical drugs were also evaluated through screening against nucleoprotein
• OMS, CBX, LGH,
• Naproxen,
• BMS-883559
• BMS-885838 [9]
• Hyperoside from neem leaf extract
• With drugs LGH, Naproxen, BMS-885838, and BMS-883559
• Showed best interactions with conserved residues of nucleoprotein
• These compounds have been identified for their potential against influenza strains to be utilized as a universal drug [9]

• www.ncbi.nlm.nih.gov/pubmed/27986088