Fyziologie, zajímavosti, historie

neem oil limonoids

• Induce p53-independent apoptosis and autophagy

Potent spermicide effects

• 100 mg of dried leaf powder suspended in 1 ml of distilled water for a 24 h period
• Lower dosages seem to affect the motility of the sperm
• Hence acting as an ATPase inhibitor (Khillare & Shrivastav, 2003)
• www.sciencedirect.com/science/article/pii/S1756464620303959

• Uncouple mitochondrial oxidative phosphorylation
• Inhibiting the respiratory chain

• Nimbidin, nimbin, nimbolide, gedunin, mahmoodin, margolone, and cyclic trisulfide
• Contribute to the antibacterial activity of neem (Al Akeel et al., 2017, Heyman et al., 2017, Khamis Al-Jadidi and Hossain, 2015, Shah et al., 2016)

• Inhibitors of topoisomerase I and II, alkylating agents, and microtubule inhibitors (Thompson et al., 2014, Thompson et al., 2016).

• Neem, Ganoderma spore, Wanirin, Chaga enzymes and rice, to block the progression of colon cancer to a metastatic state (Tanaka, 2019).

• www.sciencedirect.com/science/article/pii/S1756464620303959

Neem genome and transcriptomes

• From various organs
• Sequenced, analyzed and published
• www.ncbi.nlm.nih.gov/pubmed/26290780