potraviny/clitoria-ternatea/biochemicke-slozeni-a-medicinsko-kucharske-vyuziti
Anti-inflammatory in oral lesions
- Anthocyanins from dietary sources showing potential benefits
- Developed as an anthocyanin complex (AC)
- Extracts of Zea mays (CC) and Clitoria ternatea (CT)
- Formulated into a niosome gel
- Delivery depots of anthocyanins, following encapsulation in niosomes and incorporation into a mucoadhesive gel
- Collagen production in human gingival fibroblasts was promoted by AC and AC niosomes, but not CC or CT [2]
Antihyperglycemic activity
- Clitoria ternatea flower extract (CTE) on postprandial plasma glycemia response
- Randomized, crossover study, 15 healthy men (ages 22.53?±?0.30 years; with body mass index of 21.57?±?0.54 kg/m2)
- Consumed five beverages:
- (1) 50 g sucrose in 400 mL water;
- (2) 1 g CTE in 400 mL of water;
- (3) 2 g CTE in 400 mL of water;
- (4) 50 g sucrose and 1 g CTE in 400 mL of water;
- (5) 50 g sucrose and 2 g CTE in 400 mL of water [4]
- Incremental postprandial plasma glucose, insulin, uric acid, antioxidant capacities and lipid peroxidation were measured during 3 h of administration.
- After 30 min ingestion, the postprandial plasma glucose and insulin levels
- Were suppressed when consuming sucrose plus 1 g and 2 g CTE
- Consumption of CTE alone did not alter plasma glucose and insulin concentration in the fasting state [4]
Increase in plasma antioxidant capacity
- Observed in the subjects who received 1 g and 2 g CTE:
- Ferric reducing ability of plasma (FRAP)
- Oxygen radical absorbance capacity (ORAC)
- Trolox equivalent antioxidant capacity (TEAC)
- protein thiol
- Decrease in malondialdehyde (MDA) level
- Consumption of CTE protected sucrose-induced reduction in ORAC and TEAC and increase in plasma MDA [4]
- Acute ingestion of CTE increases plasma antioxidant capacity without hypoglycemia in the fasting state
- Improves postprandial glucose, insulin and antioxidant status when consumed with sucrose [4]
- TRIAL REGISTRATION:
- Thai Clinical Trials Registry: TCTR20170609003 . Registered 09 September 2017. 'retrospectively registered' [4]
Arthritis
- Clitoria ternatea Linn. (C. ternatea) traditionally used as anti-arthritic
- Polyphenols (e.g. quercetins) from its flower petal.
Does C. ternatea or quercetin-3ß-D-glucoside (QG) support the antibody mediated TNF?-receptor 1 (TNFR1) neutralization to ameliorate arthritis in mice ?
- collagen-induced arthritis (CIA) in male Swiss mice (20-22g, 3-4 weeks of age)
- CIA was induced from day 2 post-secondary immunizations as evidenced from arthritic scores and joint swelling
- In parallel to increased inflammatory and oxidative stress parameters in synovial joints
- Long term supplementation with extract from Clitoria ternatea flower petals CTE (50mg/kg) and QG (2.5mg/kg) upto 24 days post booster immunization
- Augmented anti-arthritic potential of TNFR1 neutralization with anti-TNFR1 antibody (10µg per mice)
- Reduced MPO activity
- Decrease in release of pro-inflammatory cytokines, chemokines, reactive oxygen species (ROS)/ reactive nitrogen species (RNS) production
- In parallel to significant reduction in TNFR1, TLR2, iNOS, COX-2 and MMP-2 expression [5]
- CTE and QG possess potential anti-arthritic activity
- Targets synovial MMP-2 in arthritic joints
- TNFR1 targeting followed by CTE or QG treatment might become a combinatorial approach in future therapeutic research in treatment of arthritis [5]
Ayurvedic medicine
- Memory enhancing, nootropic
- Antistress, anxiolytic, antidepressant
- Anticonvulsant, tranquilizing, sedative [1]
Natural food colouring
- Southeast Asia
- As bunga telang
- In Malay cooking
- Aqueous extract is used to colour glutinous rice for
- Kuih ketan = pulut tai tai = pulut tekan in Peranakan/Nyonya cooking, in nyonya chang
- In Kelantan, east part of Malaysia
- Adding a few buds of this flower in a pot while cooking white rice will add bluish tint on the rice
- Nasi kerabu
- In Thailand
- Syrupy blue drink is called nam dok anchan
- Sometimes consumed with a drop of sweet lime juice to increase acidity
- Turn the juice into pink-purple
- In Burmese and Thai cuisines
- Flowers are also dipped in batter and fried
- Butterfly pea flower tea
- From the ternatea flowers and dried lemongrass
- Changes color depending on what is added to the liquid
- With lemon juice turning it purple [1]
- Botanical in a colour-changing gin
- Blue in the bottle, this turns pink when mixed with a carbonated mixer such as tonic water [1]
Cyclotides
- Plant-derived, cyclic miniproteins with three interlocking disulfide bonds
- Excellent stability
- Potential as peptide therapeutics
- Cyclotides of the medicinal plant Clitoria ternatea (butterfly pea)
- Identified 41 novel cyclotide sequences, which we named cliotides
- C. ternatea one of the richest cyclotide-producing plants to date [8]
- Selected members of the cationic cliotides display potent antibacterial activity
- Specifically against Gram-negative bacteria
- Minimal inhibitory concentrations as low as 0.5 µm [8]
- Prominent immunostimulating activity
- 1 µm, cationic cliotides are capable of augmenting the secretion of various cytokines and chemokines
- Cyclotides can serve as potential candidates for novel immunomodulating therapeutics [8]
Protective effect against hydrogen peroxide-induced cytotoxicity
- C. ternatea flower water extract (CTW) against hydrogen peroxide-induced cytotoxicity and ultraviolet (UV)-induced mitochondrial DNA (mtDNA) damage in human keratinocytes
- CTW also significantly reduced mtDNA damage in UV-exposed HaCaT
- Main compounds detected:
- Anthocyanins derived from delphinidin
- Including polyacylated ternatins
- Flavonol glycosides
- Derived from quercetin and kaempferol [3]
- Against H2 O2 and UV-induced oxidative stress on skin cells
- Some explanation for the putative traditional and cosmetic uses of C. ternatea flower against skin aging [3]
Traditional Chinese medicine
- Affecting female libido due to its similar appearance to the female reproductive organ
Various triterpenoids
Flavonol glycosides
Anthocyanins and steroids
Cyclic peptides
Cliotides
- From the heat-stable fraction of C. ternatea extract [1]
