3-Hydroxyphenyl-3hydroxypropionic-acid

HPHPA (3-hydroxyphenyl-3-hydroxypropionic acid)

• Popular companies: Great Plains
• What the company says it indicates: Clostridium spp. (C. sporogenes, C. caloritolerans, C. botulinum & others)
• Elevated urinary marker in autism spectrum disorders, as well as schizophrenia
• Treatment of autistic children with the broad-spectrum antibiotic vancomycin
• Dramatically reduced urinary HPHPA
• Suggesting a strong microbial link
• HPHPA is often suggested to be a biomarker of Clostridium species
• We were unable to find any evidence to support this.
• Influenced by the microbiome and elevated in psychiatric disorders
• No evidence to support this as a marker of Clostridium overgrowth.
• www.lucymailing.com/the-uses-and-limitations-of-organic-acids-testing-for-gut-health-a-complete-guide/?utm_source=substack&utm_medium=email