3-hydroxyphenylacetic

3-Hydroxyphenylacetic Acid (3HPAA)

• Popular companies: Genova
• Bacterial dysbiosis
• Like 2HPAA, 3HPAA is an established biomarker for disturbed phenylalanine metabolism
• Well-established bacterial byproduct of polyphenol metabolism
• Used as a biomarker of polyphenol intake in clinical research
• Wine and grape consumption
• Laboratory models of human digestion
• The most abundant bacterial metabolite of tomato and “pressure-processed onion”
• Exercise increases 3HPAA in mice
• Rodent research
• May contribute to the cardioprotective effects of exercise after a heart attack
• Low fecal 3HPAA
• Distinguished individuals with colorectal cancer or adenomas from healthy controls
• Single study of children with autism
• Oral vancomycin decreased markedly elevated baseline levels of 3HPAA
• Gut populations of vancomycin-sensitive microbes may contribute to pathologically elevated levels
• Likely reflects dietary intake, lifestyle, and phenylalanine metabolism more than bacterial populations.
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