4-Hydroxyphenylacetic Acid

4-Hydroxyphenylacetic Acid (4HPAA)

• Popular companies: Genova, Great Plains, Diagnostic Solutions
• Companies say it indicates: Bacterial dysbiosis; C. difficile, C. stricklandii, C. lituseburense & others
• Close relative of 3HPAA
• One of the primary microbial metabolites of resveratrol
• At high levels in red wine
• 4HPAA also increases when you eat
• Strawberries
• Bacterial metabolism of the amino acid tyrosine
• 4HPAA was among the most significantly increased blood metabolites in individuals with ulcerative colitis
• Recent study found that 4HPAA alone
• Sufficient to reduce diet-induced cardiometabolic disease in mice
• No studies have directly correlated urinary levels with bacterial populations.
• Likely reflects dietary polyphenol and amino acid intake more than bacterial composition
• More research is needed to clarify its health effects.
• www.lucymailing.com/the-uses-and-limitations-of-organic-acids-testing-for-gut-health-a-complete-guide/?utm_source=substack&utm_medium=email