leky-latky/cftr-protein/dalsi-leciva-pri-CF

Digitoxin

• As a Wt CFTR-gene therapy mimic
• Inhibits TNFalpha/NFkappaB signaling and IL-8 hyperexpression in CF lung epithelial cells
• Target of digitoxin action was the interaction between TNFR1 and TRADD

• www.karger.com/Article/FullText/453162

CFTR therapeutics

• Positive effects on the functional characteristics of their immune cells (Zhang et al., 2018)

• www.frontiersin.org/articles/10.3389/fphys.2020.583862/full