leky-latky/cftr-protein/mutace/mutace-3

Class III mutations

• Disrupt the function of the regulatory domain.
• CFTR is resistant to phosphorylation or adenosine tri-phosphate (ATP) binding.
• Impair channel gating (Class III)

CFTR activators such as

Alkylxanthines (CPX)

Flavonoid genistein

• Can overcome affected ATP binding through direct binding to a nucleotide binding fold.