leky-latky/cftr-protein/mutace/mutace-4

Class IV mutations

• Phosphorylation of CFTR results in reduced chloride transport
• Increases in the overall cell surface content of these mutants might overcome the relative reduction in conductance
• Restoring native chloride pore characteristics pharmacologically might be effective
• Impair anion permeation through the open pore (Class IV) (De Boeck and Amaral, 2016).

Activators of CFTR at the plasma membrane

• May function by promoting CFTR phosphorylation
• By blocking CFTR dephosphorylation
• By interacting directly with CFTR
• By modulation of CFTR protein-protein interactions [8]