H3 receptory

H3 exprese

• Výhradně v centrálním nervovém systému

Aktivace H3 receptorů

• Snižuje produkci a uvolňování acetylcholinu, serotoninu a norepinefrinu
• Hraje důležitou roli u poruch spánku a pozornosti
• Related to cognitive function and the maintenance of short and long-term memory.

H3 receptor

Central nervous system + Peripheral nervous system tissue

• Autoreceptor and heteroreceptor functions
• Decreased neurotransmitter release of histamine, acetylcholine, norepinephrine, serotonin
• Modulates
• Nociception
• Gastric acid secretion
• Food intake [1]

• Histamine nerves (histaminergic cell bodies)
• Originate in hypothalamus (HPT) known as the tuberomammillary nucleus
• Project to almost every region of the CNS
• With extensive projections to the cerebral cortex
• Cognitive and sleeping disorders