H4 receptory
H4 receptor
- Primarily on basophils
- Bone marrow
- Expressed in the thymus
- Small intestine
- Spleen
- Colon
- Mast cell chemotaxis
- Itch perception
- Cytokine production and secretion
- Visceral hypersensitivity
- Inflammation, allergy, cognition, etc.) have not been fully characterized
Cévní permeabilita
- Vascular hyperpermeability and vasodilation
- Histamine binding to endothelial cells causes them to contract
- Increasing vascular leak
- Stimulates synthesis and release of various vascular smooth muscle cell relaxants
- nitric oxide
- Endothelium-derived hyperpolarizing factors
- Resulting in blood vessel dilation
- Key role in the pathophysiology of anaphylaxis [1]
Receptory H4 exprese
- Hlavně na buňkách krve
- Leukocytech
- žírných buňkách
- Lamina propria a submukózy
- Slezině,
- Brzlíku,
- Kostní dřeni,
- Lymfoidní tkáni ve střevním epitelu
- V neuroendokrinních buňkách
- Ve žlučových a pankreatických vývodech
Stimulace H4
- V rozvoji zánětu a hypersenzitivní reakcí.
- On immune system cells, including
- Mast cells,
- Eosinophils,
- T-cells,
- Dendritic cells.
- Modulate immune responses.
- histamine attaches to them
- Cells migrate to the affected area.
- Excess histamine eventually lead to chronic inflammation and allergic responses
- H4 receptors
- Dendritic cell activation
- Th0 cell differentiation (I.e. Th0 becoming TH2 cells)
- www.drphelts.com/our-blog/six-ways-to-combat-allergies-allergycure-chiropractor-10017-10016-new-york-ny-manhattan
