Inositol 6 fosfát - IP6

Colorectal cancer

• Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells

mTOR1

• Is oncogenic
• Facilitates intracellular signaling
• Used by cancer cells for survival and growth
• MTOR1 is a negative regulator of autophagy via binding to the Atg13-ULK1/2-FIP200 complex
• Phosphorylation of the complex components, and inhibition of autophagy
• Nutrient deprivation results in the release of mTOR1 and dephosphorylation of ULK1/2 and Atg13
• Hence facilitates the activation of autophagy

Inositol 6 phosphate

• Potent chemotherapeutic agent
• Killing HT-29 human colon cancer cells hypothesized that IP6 inhibits mTOR signaling
• Leading to the activation of autophagy-mediated death in HT-29 colon cancer cells.

• Arch Med Sci. 2018 Oct; 14(6): 1281–1288. Published online 2018 Jul 5. doi: 10.5114/aoms.2018.76935 PMCID: PMC6209706

Kombinace

• Nejkonzistentnějších a nejlepších protinádorových účinků bylo dosaženo kombinací IP6 a inositolu.

• ip6-a-inositolu-7976">www.veterinarni-lekari.cz/tema/verinarni-pece/detail/inhibice-rustu-nadoru-po-podani-inositol-hexafosfatu-ip6-a-inositolu-7976

Výskyt

• 1–5% by weight of most cereals, nuts, oilseed, legumes, and grains.
• Inositol 6 phosphate, which occurs at 9.5–14.5% by weight in rice bran
• In vivo and in vitro experiments
• Provide convincing evidence for the anti-carcinogenic effects of IP6