Spektrum a mechanismus účinku
Glycerol monolaurate jako přísada do krmiv
- Medium chain fatty acids(MCFAs)
- Can promote animal health and improve growth performance
- Superior to antibiotics in fighting bacteria and viruses
- More beneficial to animal health
- Good antiviral properties against enveloped viruses
- African swine fever ASF,
- Blue ear disease PRRSV,
- Swine fever,
- Avian influenza,
- Pseudorabies, etc.
- Is resistant to a variety of bacteria in the feed
- Staphylococcus aureus,
- Bacillus subtilis,
- Yeast ,
- Aspergillus niger,
- Penicillium glaucum
- Have obvious inhibitory effect.
- Monolauric acid
- Can cause the membrane protein of enveloped virus to leak out.
- Glyceryl monolaurate
- Can be absorbed into bacteria or enveloped viruses
- Cause the splitting of the outer shell membrane of the viral ester
- Virus replication ability is weakened or lost - act as antigens
- Will stimulate animals to produce corresponding antibodies
- GML has the strongest inhibitory effect on
- G + bacteria and some G-bacteria
- Inhibit the proliferation of harmful bacteria,
- Reduce intestinal ineffective fermentation,
- Remove endotoxins from the body.
- Anti-enveloped viruses
- AIDS,
- Blue ear disease,
- Swine fever,
- Influenza, etc.),
- Absorbed through the intestinal wall into the body's lymph and blood circulation
- More effectively fight virus replication and spread
- Relieve immune suppression,
- Promote immune organs ( Spleen and thymus) growth and development.
- wellgochem.com/monolaurate?gclid=CjwKCAjw6p-oBhAYEiwAgg2PgvBy6GigdypcPXuYOtGQPZIzi9poWyf0_BejLTEHZ2VEgLTgh5TZBhoCmYIQAvD_BwE
Antiviral properties Glycerol monolaurate
- Against a number of enveloped viruses
- HIV-1, HSV-1, measles, cytomegalovirus, yellow fever virus, mumps virus, Zika virus, influenza, and CoVs (Subroto & Indiarto, 2020)
- It did not show any inhibitory effect on nonenveloped viruses
- Association with direct viral envelope interference and modulatory changes in it (Welch et al., 2020)
- Loss of virus infectivity due to generalized disintegration of envelope
- Influenza A and CoV coincubated with a GML mixture on
- Primary rhesus monkey kidney (MK) cells,
- Human laryngeal epidermoid carcinoma cell line (HEp-2)
- Human embryonic lung diploid fibroblast cell strain (HELF)
- SARS-CoV-2 also possesses characteristics similar to that of enveloped viruses including membrane and core of virus composed of phospholipids and RNA genome
- www.ncbi.nlm.nih.gov/pmc/articles/PMC10261805/
