leky-latky/neutrofily/funkce

Effector functions

• Infiltrate damaged tissue and fight pathogens
• If neutrophils do not encounter pro-inflammatory signals or signals to prolong life
• Undergo apoptosis within days of release from the bone marrow (Geering and Simon 2011)
• Neutrophils infiltrate the infected tissue by transmigration through the endothelium and epithelium
• Arriving at the site of infection - four main effector functions
• Facilitate the clearance of pathogens
• Promote further neutrophil recruitment

• Phagocytosis
• ROS production
• Degranulation
• Neutrophil granules develop sequentially in a process called granulopoiesis.
• Neutrophil extracellular trap (NET) formation

Neutrofily

• Recruitment of neutrophil to the interstitial tissue
• Release of matrix metalloproteases
• Generates N-acetyl-PGP
• Recruiting more neutrophils [23]

• Necrotic neutrophils, not cleared by macrophages
• Lyse and release DNA, protease and ROS
• Promote airway obstruction
• Remodel the airway causing a loss of lung function [23]