NRF2

Nrf2-interacting nutrients

• berberine,
• curcumin,
• Epigallocatechin gallate,
• Genistein,
• Quercetin,
• resveratrol,
• Sulforaphane
• MSM
• Glutahtion a jeho prekurzory
• NAC
• ALA

• Reduce insulin resistance, endothelial damage, lung injury and cytokine storm.
• May as a result be important in mitigating the severity of COVID-19
• Acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway
• Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1
• pubmed.ncbi.nlm.nih.gov/33292691/

Tecfidera

• Less potent Nrf2 activators (sulforaphane [26,118], curcumin [25,119,120] and resveratrol [27,28,121]) have been developed, tested and demonstrated for use in some of these indications, however do not appear to exert the same influences on innate and adaptive immunity as FAEs.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602023/

• Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2.
• Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators.
• Three examples are: kimchi in Korea, westernized foods, and the slum paradox.

https://pubmed.ncbi.nlm.nih.gov/32762135/