Organické kyseliny - OTA

Genova, Great Plains, and Diagnostic Solutions

• Include sections on their reports for markers of bacterial and yeast overgrowth
• Markers for bacterial and fungal overgrowth
• Markers for detoxification, cellular metabolism,
• Neurotransmitter balance,
• Nutrient deficiencies,
• mitochondrial health

Mass spectrometry combined with liquid chromatography (LC/MS)

• Lab technicians can separate metabolites based on their structure and measure their concentrations.
• www.lucymailing.com/the-uses-and-limitations-of-organic-acids-testing-for-gut-health-a-complete-guide/?utm_source=substack&utm_medium=email

Metabolomics

• Is becoming an increasingly important part of scientific research on the microbiome
• Stool tests can tell us which microbes are present in the gut
• Metabolomics is an attempt to tell us what the microbes are actually doing.

Organic acids testing

• Sounds great in theory – measure the activity of the microbes
• You can get a better idea of their activity in the gut.
• Several factors complicate their ability to provide a clear clinical picture
• Many common OAT “microbial” metabolites are found in the diet
• Others are generated endogenously (in the body)
• Others appear to respond more to age, toxin exposure, or recent dietary intake
• Than the presence of particular microbes in your gut.
• Very few of the microbial markers on OAT are reliable measures of what they purport to measure.

Who should get an organic acids test?

• Limited use for assessing gut health in most cases
• Stool testing currently offers a more reliable method to assess the overall state of the gut microbiome.
• Select few OAT markers are rooted in evidence and may be beneficial for specific use cases
• www.lucymailing.com/the-uses-and-limitations-of-organic-acids-testing-for-gut-health-a-complete-guide/?utm_source=substack&utm_medium=email

MyMycoLab lab

• Blood antibody test for IgG and IGE antibodies against a large variety of mycotoxins
• Dr. Andrew Campbell owns and operates the lab and is an environmental doctor treating mold for 40+ years
• I run Mymycolab and I have never seen false positives on it.
• I’ve been in practice 20 years, and I’ve been treating mold for the last decade
• I also went through my old illness myself for years ago.
• Dr. Campbell is always happy to take time to discuss different mold testing, his experience and the lab that he offers.

Angela Pifer, FMN, CN, LN, FUNCTIONAL GUT STORE FOUNDER

Tartaric acid diskuze

• Has a very HIGH SPECIFICITY when it comes to mold.
• Every time I have seen that marker go up, the child/individual was impacted by mold

Pejman

How often OATs MISS mold

• Neil Nathan was the first to bring this to my attention
• Several hundred pediatric mold cases, I find the sensitivity of the mold markers from either company to be at best 50% (1/2 cases are MISSED if you are solely relying on an organic acid).
• Clinical judgement must rule supreme.

Pejman

Diskuze k testování IgG na mykotoxiny

• So when it comes to patients who are sick *with known recent or current* environmental mold exposure
• If they've *never been treated before* for mycotoxins
• If they have an IgG(+) mycotoxin result
• I'd certainly correlate the two results
• But if someone was known to be exposed to mold toxins 5 years ago and treated both their environment as well as their body
• (say, for a full year - and for argument's sake, let's say there's no evidence/suspicion of internal bodily mold colonization),
• And they have a (+) IgG set now
• I can't tell if that's residual IgG from 5yrs ago with no currently present mycotoxin,
• Or if they might actually still have mycotoxins now.
• Even if they are still currently symptomatic, I'm left with the question:
• "is this person's symptoms (whatever they may be -fatigue, pain, brain fog, paresthesias, IBS, etc) due to mycotoxins?
• Or might they be due to tickborne illness?
• Or even due to chronic mono, or radiated metals, or heavy metals, or EMFs, or oxalates, or ...?"
• "what *combo* of Exposome entities might be causing this person's symptoms,
• Esp. exclusive of mycotoxins, given that they've had mycotoxins meaningfully treated before?"
• If they have no mycotoxins now,
• But I interpret the (+) antibodies as current mycotoxins (+),
• Then I'm treating them for nothing
• Actual target(s) of their symptoms are other Exposome entities
• I've misdiagnosed them and am doing them wrong

• I'm not against antibody testing for mycotoxins.
• Repeat/follow-up testing after treating someone
• Even less reason to do antibody testing.
• Just like with tickborne testing.
• I'm not against western blot testing on follow up
• But it's very challenging for interpreting results
• If the antibody levels are unchanged, does that really mean ?
• If the antibody marker profile has changed (some antibodies are new, while others are lessened/gone)
• Does that mean the person has encountered a new tick bite?
• It's very imprecise, and very much art, much less science
• If given the option of direct vs. indirect testing, I'll choose the direct testing
• Direct testing seems more reliable with urine mycotoxin testing
• Than it does blood PCR testing for tickborne pathogens ( pathogens don't tend to reside in the bloodstream)
• Very limited sample of blood - higher false negatives with the PCR tickborne tests vs. the urine mycotoxin tests)
• Urinary direct testing for follow up, then for the sake of a baseline for future comparison of results
• If the antibody immune system is recovering as a result of addressing the Exposome problem
• Could I get higher antibody levels with time, which might look like there's more of a problem, as a false interpretation?
• Problem for mycotoxins or tickborne pathogens
• If they're on IVIg or SCIg, then it's all up
• If a patient has never been treated for mycotoxins,
• Have a (+) IgG test
• Taking that as confirmation of mycotoxin illness (corresponding to whatever symptoms)
• Follow up testing that is trickier, post-treatment

Mark