Bezpečnost

Safety

• PEA is generally considered safe
• Without adverse drug reactions (ADRs) or drug interactions
• PEA may be considered likely to interact with other PPAR-a agonists used to treat high triglycerides; this remains unconfirmed.

2016 study assessing safety claims in sixteen clinical trials, six case reports/pilot studies and a meta-analysis of PEA as an analgesic

• For treatment periods up to 49 days,
• Clinical data argued against serious ADRs at an incidence of 1/200 or greater

A 2016 pooled meta-analysis involving twelve studies

• Found that no serious ADRs were registered and/or reported
• No data on interactions with PEA have been reported.