Historie

History PEA

• Palmitoylethanolamide was discovered in 1957
• Anti-inflammatory and analgesic date from before 1980
• N-(2-hydroxyethyl)-palmitamide
• Natural anti-inflammatory agent
• Crystalline anti-inflammatory factor from soybean lecithin
• (S)-(2-hydroxyethyl)-palmitamide
• Isolated from a phospholipid fraction of egg yolk
• From hexane-extracted peanut meal
• 1975, Czech physicians described the results of a clinical trial
• Aspirin versus PEA were tested
• Both drugs were reported to enhance joint movements and decrease pain
• 1970 the drug manufacturer Spofa in Czechoslovakia - Impulsin
• A tablet dose of PEA, for the treatment and prophylaxis of influenza and other respiratory infections
• Spain, the company Almirall introduced Palmidrol
• In tablet and suspension forms in 1976, for the same indications
• Mid-1990s
• Relationship between anandamide and PEA was described
• Expression of mast cell receptors sensitive to the two molecules was demonstrated by Levi-Montalcini and coworkers
• Oleamide, palmitoylethanolamide, 2-lineoylglycerol and 2-palmitoylglycerol
• Explored for their capacity to modulate pain sensitivity and inflammation