Neurotrauma

Po trauamtu nervové soustavy

Spinal trauma model

• PEA reduced the resulting neurological deficit via the reduction of mast cell infiltration and activation
• Reduced the activation of microglia and astrocytes

Po CMP

Models of stroke and other CNS trauma

• PEA exerted neuroprotective properties
• 2012 it became clear that PEA can also reduce reperfusion injury
• Reverse negative impact of shock on various outcome parameters, such as
• Renal dysfunction,
• Ischemic injury
• Inflammation
• Most probably via the PPAR-alpha pathway
• PEA could reduce the increase in
• Creatinine, GGT, AST, nuclear translocation of NF-kBp65
• Kidney MPO activity
• MDA levels,
• Nitrotyrosine,
• PAR
• Adhesion molecules expression
• Infiltration and activation of mast cells and apoptosis