Phenylpropionic-acid
Anaerobic gut flora
- Phenylpropionic acid (PPA) a compound similar to PAA with two –CH2– groups instead of one
- Also produced by anaerobic gut flora
Clinical Applications of Urinary Organic Acids. Part 2. Dysbiosis Markers, Richard S. Lord, PhD, and J. Alexander Bralley, PhD, Alternative Medicine Review Volume 13, Number 4 2008
Snap in mitochondrial medium-chain acyl-CoA-dehydrogenase (MCAD) and clostridia
- PPA does not normally appear in human urine
- Is metabolized by mitochondrial medium-chain acyl-CoA-dehydrogenase (MCAD)
- Glycine conjugate of PPA
- 3-phenylpropionylglycine
- Proposed as a marker for diagnosing asymptomatic MCAD-deficient individuals who do not sufficiently carry out the oxidative step
- This human genetic polymorphism test is unique
- Dependent on the production of PPA by gut flora such as Peptostreptococcus anaerobius
- Of 67 bacterial and five yeast isolates examined only the
- Three isolates of Clostridium sporogenes
- One of Clostridium difficile produced PPA
Clinical Applications of Urinary Organic Acids. Part 2. Dysbiosis Markers, Richard S. Lord, PhD, and J. Alexander Bralley, PhD, Alternative Medicine Review Volume 13, Number 4 2008
Microbial overgrowth
- Can include
- benzoate,
- Hippurate,
- Phenylacetate,
- Phenylpropionate,
- cresol,
- Hydroxybenzoate,
- Hydroxyphenylacetate,
- Hydroxyphenylpropionate
- 3,4-dihydroxyphenylpropionate,
- Indican,
- Tricarballylate,
- D-lactate,
- D-arabinitol
