Piperin

Piperine

• Enhances absorption is by inhibiting human P-glycoprotein
• Inhibitis cytochrome CYP3A4
• Both the proteins contribute to a major extent to first-pass elimination of many drugs (which we want to avoid)

• Stojanovic-Radic, 2019. Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies
• P–glycoprotein inhibition can also help some drugs to cross blood-brain barrier. E.g. paclitaxel (Kemper, 2003)

Avoid piperine during chemotherapy

• Can influence metabolism of many drugs, especially those metabolised by CYP3A4
• More than 50% of drugs on market
• P-glycoprotein (P-gp) inhibition = higher risk of drug toxicity / effectivity
• Bude záležet na tom, jak moc léčivo působí selektivně na nádorové buňky

Cannabis

• piperine boosts both THC and CBD.
• THC it is 3 fold increase in maximum serum concentration
• CBD it is 4 fold

• piperine for the very first time
• Try it alone and wait about 1 hour. It might cause stomach pain in some people, especially if they have gall bladder problems.

Products

• Source Naturals 120 tablet (iHerb) 10mg in a capsule.
• Swanson 60 capsules 10mg in a capsule.
• You can buy it in bulk as powder and fill in your capsules
• Requires a sensitive digital scale
• Amount is very low and you should be careful and precise with dosing

• PS: You mix all the ingredietns in the right ration and than just fill in the capsules