Sekretagoga

Sevoflurane

• On cAMP-induced chloride secretion by the mouse tracheal epithelium
• CFTR current was not affected by sevoflurane (approximately 360 microM)
• Inhibition of KCNQ1 underlies sevoflurane-induced decrease in airway secretion

• www.researchgate.net/publication/6268809_Effects_of_sevofiurane_on_the_cAMP-induced_short-circuit_current_in_mouse_tracheal_epithelium_and_recombinant_Cl-_CFTR_and_K_KCNQ1_channels

Secretagogues mobilizing Ca2+ from endoplasmic reticulum (ER)

• Acetylcholine
• ATP
• Induce secretion by stimulating Ca2+ - activated Cl-channels (CaCCs)

• physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/jphysiol.2013.261909