LPS toxin

LPS activation of toll-like receptor4 pathway

• Upregulates aerobic glycolysis (zadýchávání se)
• Upregulates fatty acid synthesis (tloustnutí)
• Reduction in mitochondrial respiration (unava)
• Reduction of beta-oxidation in macrophages (snížení energie pro makrofagy)
• Succinate and citrate accumulate
• Accumulation of citrate drives
• mitochondrial ROS (mtROS) (stárnutí)
• nitric oxide accumulation (překrvení, prosaky ?)
• itaconate production
• Contributes to the proinflammatory phenotype of M1-like macrophages ????
• Acetyl-CoA to build up (tloustnutí)
• Histone acetylation
• Facilitating transcription of inflammatory genes

Targeting immunometabolism to treat COVID-19 Shane M. O’Carroll*, and Luke A. J. O’Neill School of Biochemistry and immunology, Trinity Biomedical ciences Institute, Trinity College Dublin, Dublin, Ireland *Correspondence: Shane M. O’Carroll, School of Biochemistry and immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. Email: shocarro@tcd.ie Received 15 March 2021; Revised 7 May 2021; Accepted 31 May 2021