nemoci-sympt/BAKTERIALNI-INFEKCE/LPS-toxin
LPS activation of toll-like receptor4 pathway
- Upregulates aerobic glycolysis (zadýchávání se)
- Upregulates fatty acid synthesis (tloustnutí)
- Reduction in mitochondrial respiration (unava)
- Reduction of beta-oxidation in macrophages (snížení energie pro makrofagy)
- Succinate and citrate accumulate
- Accumulation of citrate drives
- mitochondrial ROS (mtROS) (stárnutí)
- nitric oxide accumulation (překrvení, prosaky ?)
- itaconate production
- Contributes to the proinflammatory phenotype of M1-like macrophages ????
- Acetyl-CoA to build up (tloustnutí)
- Histone acetylation
- Facilitating transcription of inflammatory genes