nemoci-sympt/BAKTERIALNI-INFEKCE/chlamydie/symptomy-a-asociovana-onemocneni/borrelioza

Borreliové koinfekce ve vztahu k roztroušené skleroze a ATB terapii

• Makes sense to use a schedule of antimicrobial agents which is effective against other potential pathogens of the CNS
• Including Borrelia garini and B burgdorferi
• Cause a serologically negative MS-like illness with white-matter MRI changes
• Generally difficult to detect serologically
• EIA test is particularly prone to giving false negative results
• Chronic borreliosis
• May be much more prevalent than is now believed
• B. burgdorferi
• Identified in avian ticks infesting songbirds
• Posited as a reservoir of borrelial infection in Europe
• Chronic C pneumoniae infection causing a decreased efficiency of host systems
• May prevent resolution of borreliosis

Další možné chronické patogeny v CNS při MS

• Make sense ATB to cover for
• Rickettsiae
• Mycoplasma sp.
• Cell-wall deficient forms

• MS and other initially relapsing-remitting but ultimately progressive diseases
• May have a polymicrobial phase
• Punctured vasculitis caused by Chl pneumoniae
• Provide an easy portal of tissue-entry for blood-borne organisms

• Many chronic infections
• Provides a niche for a host of secondary organisms
• Chronic HIV disease etc.

• The earlier that treatment is begun the better the result and the more complete the resolution [43]