Generation of formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLP)-induced superoxide anion by human neutrophils is inhibited by 2S-7'-hydroxyflavanone [55]. The number of viable Streptococcus pneumoniae in the lung decreased upon administration of 7'-hydroxyflavanone (1 mg/mouse) and Zuccagnia punctata extract (ZpE) (1 mg/mouse). The intake of Flavonoid 7HF extracted from Zuccagnia punctata or Zuccagnia punctata extract once or twice a day could be a potential treatment for respiratory infections [56]. An increase in the levels of P-glycoprotein (P-gp) expression was observed in HK-2 cells in the presence of ZpE or dihydroxyflavone (DHF) for 72 hrs, whereas the activity of HK-2 cells either dropped or remained unchanged. No effect of 7HF was observed in HK-2 cells [57]. Apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in HeLa cancer cells was amplified by 6-hydroxyflavanone (6-HF) and its derivative 6-propionoxy-flavonone (6-PF). A decrease in the mitochondrial membrane potential and an increase in the expression of the TRAIL-R2 death receptor led to the apoptosis of HeLa cells. Therefore, flavonones can be of potential use in TRAIL-based anticancer therapy, as they magnify the anticancer effects of TRAIL [58].https://www.mdpi.com/2076-3417/12/19/9543
