nemoci-sympt/DERMATOLOGIE/pigmentace-pokozky/chloasma-melasma/popis

Melasma

• Acquired chronic pigmentary disorder
• Skin microenvironment of melasma lesions
• Skin barrier dysfunction and abnormal synthesis, transport, and intracellular distribution of melanin in the epidermis
• Basement membrane damage
• Solar elastosis, vascular changes, senescent fibroblasts, mast cell infiltration, and sebocyte participation in the dermis
• Systemic sex hormones and oxidative stress
• onlinelibrary.wiley.com/doi/10.1111/ijd.17453