nemoci-sympt/HEMATOLOGIE/leukemie-lymfoblasticka/zlepseni

Rosemary extracts

• Active compounds carnosic acid
• Rosmarinic acid
• Inhibit the proliferation of various human cancer cell lines, including
• NCI-H82 (human, small cell lung carcinoma)
• DU145 (human prostate carcinoma)
• Hep-3B (human [black] liver carcinoma)
• K-562 (human chronic myeloid leukemia)
• MCF-7 (human breast adenocarcinoma)
• PC-3 (human prostate adenocarcinoma)
• MDA-MB-231 (human breast adenocarcinoma; Yesil-Celiktas et al. 2010)
• Decrease in TNF-?-induced ROS generation and NF-?B activation
• Enhanced TNF-?-induced apoptosis (Moon et al. 2010)
• Carnosol
• Was the most effective in reducing tumor proliferation
• Induce apoptotic cell death in high-risk pre-B acute lymphoblastic leukemia (ALL; Dorrie, Sapala, and Zunino 2001)
• Decrease in Bcl-2
• Decreased the percentage of cell death in the pre-B ALL lines SEM, RS4;11, and REH when combined with cytarabine, methotrexate, or vincristine
• Compared to these chemotherapeutic agents alone
• Carnosol, and possibly other constituents in rosemary, may block the terminal apoptotic events induced by some chemotherapeutic drugs and therefore may decrease the effectiveness of some standard therapies for leukemia [18]
• www.ncbi.nlm.nih.gov/books/NBK92774/