nemoci-sympt/HEMATOLOGIE/leukemie-lymfocytrani-chronicka/podpurna-terapie-zlepsujici-vlivy

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• The majority of studies cited are in vitro studies, performed in glass on tissue from a living organism, or in vivo studies, performed on tissue not removed from a living organism (animal studies).
• Most studies have not advanced to clinical trials on humans.
• The few human studies cited are preliminary clinical trials.
• Therefore, although results seem favorable or unfavorable, treat them with caution.
• Neither the author nor publisher makes any medical claims for any of the herbs or natural products in this review or the tables.
• This are just study notes
• Note that some of the herbs described are deadly poisons and extremely dangerous.

EGCG from Green Tea Extract

• Chronic Lymphocytic Leukemia Complete Remissio

Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia

• Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea

by MDs and scientists at Oncology, Oregon Integrative Oncology; Block Center for Integrative Cancer Treatment, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago; Medical Oncology/Hematology, The Johns Hopkins University School of Medicine; School of Medicine, BIDMC, Harvard Medical School Office of Cancer Complementary and Alternative Medicine, National Cancer Institute, US National Institutes of Health.

• “A 48-year-old man
• Complete molecular remission 20 years after a diagnosis of chronic lymphocytic leukemia
• While using epigallicatechin-3-gallate
• Patient presented at age 28 with lymphocytosis, mild anemia, mild thrombocytopenia, and massive splenomegaly
• Splenectomy was performed
• Followed expectantly
• Next two decades, he suffered two symptomatic chronic lymphocytic leukemia-related events
• First occurred twelve years after diagnosis (at age 40)
• Patient developed fevers, night sweats, and moderate anemia
• Diagnosed with autoimmune hemolytic anemia secondary to chronic lymphocytic leukemia
• Patient declined conventional therapy in favor of a diet, exercise, and supplement regimen
• Recovered from the autoimmune hemolytic anemia though the underlying chronic lymphocytic leukemia remained evident
• Patient used
• curcumin,
• Fish oil,
• vitamin D,
• Scutellaria baicalensis,
• Epigallocatechin-3-gallate (EGCG) from green tea extract
• Timing of the remission, came shortly after an increase in dose of epigallocatechin-3- gallate to 4 g daily
• Concurrent use of curcumin
• curcumin may potentiate the antitumor effect of EGCG.
• pubmed.ncbi.nlm.nih.gov/26858922/

Neem tree leaf extract

• In the buccal pouch
• Downregulated Bcl-2 expression
• Upregulated Bim, caspase-8, and caspase-3 expression
• In chronic lymphocytic leukemia (CLL) cell viability
• Induced a dose-dependent reduction
• Significant apoptosis observed at 0.06%?(w/v) by 24?h [11]

• www.ncbi.nlm.nih.gov/pmc/articles/PMC4791507/