Myelodysplazie - MDS

Deferasirox

• Induces apoptosis by targeting oncogenic Pyk2/beta-catenin signaling in human multiple myeloma
• Expression of ferroportin correlates with clinical outcomes
• Excess of intracellular iron contributes to
• The pathogenesis of MDS
• Hepatocellular carcinoma
• Iron overload might be also associated with MM pathogenesis
• www.oncotarget.com/article/11830/text/