Epidemiologie

Rizika

Retrospective longitudinal study of 66 pediatric NAFLD patients followed for 20 years

• NAFLD is associated with higher risks of morbidity and mortality
• Compared with age and sex matched groups.
• Pediatric patients have a 13.8 fold higher risk of dying or requiring liver transplantation
• Due to liver cirrhosis when compared with the general population
• Liver-related mortality increased exponentially with each increase in the stage of fibrosis:
• Stage 1, mortality rate ratios (MMRs) = 1.41 (95% CI 0.17–11.95);
• Stage 2, MRR = 9.57 (95% CI 1.67–54.93);
• Stage 3, MRR = 16.69 (95% CI 2.92–95.36);
• Stage 4, MRR = 42.30 (95% CI 3.51–510.34)
• Higher risk of hepatocellular carcinoma was observed in adult NAFLD patients
• Regardless of whether NAFLD was associated to cirrhosis
• NAFLD is currently the leading cause for liver transplant in adults in many countries
• NAFLD represents the second cause of hepatocellular carcinoma leading to liver transplantation
• Currently the fastest rising indication for liver transplantation in patients with hepatocellular carcinoma
• Direct influence on the mortality of these patients
• www.ncbi.nlm.nih.gov/pmc/articles/PMC7698421/