GVHD - Reakce štěpu proti hostiteli

Cytokines such as interferon-?, tumor necrosis factor-? and interleukin-6 secreted by autologous T cells are closely related with the development of aplastic anemia, and HRS was reported to inhibit the levels of cytokines above.[55] Furthermore, the number of peripheral blood cells and body weight were significantly increased for aplastic anemia mice in the HRS treated groups, and the bone marrow microenvironment was also significantly improved.[55] In 2014, some scholars found that hydrogen could alleviate the spleen injury and dysfunction, avoid the damage of lymphocyte and white blood cells, and promote the proliferation function recovery of blood cell caused by radiation.[56] In addition, HRW could also alleviate total body irradiation-induced hematopoietic stem cells injury with respect to cell number alteration and to the self-renewal and differentiation of hematopoietic stem cells.[56] Acute graft-versus-host disease (aGVHD) was a lethal complication of hematopoietic stem cell transplantation, which accompanied with severe inflammatory response and oxidative stress, but these could be ameliorated by intraperitoneal administration of HRS.[57] This theory was original and probably of importance, because therapeutic medical gases had never been used for aGVHD previously.https://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=4;spage=265;epage=272;aulast=Li