nemoci-sympt/IMUNOLOGIE/mast-cells/inhibice

Účinky PEA

• Downregulates hyperactive mast cells in a dose-dependent manner
• Alleviates pain elicited in mouse models
• Anandamide also seem to have synergistic effects in models of pain and analgesia
• Variety of animal models, PEA seems to have some promise
• From multiple sclerosis to neuropathic pain
• PEA inhibits the release of both preformed and newly synthesised mast cell mediators
• histamine and TNF-alpha
• PEA + its analogue adelmidrol (di-amide derivative of azelaic acid)
• Can both down-regulate mast cells