nemoci-sympt/KARDIOLOGIE/kardiomyopatie/patofyziologie

Pathways of Pericytes in Cardiomyopathy Patients

• Single-cell RNA-seq of cardiomyopathy patients
• Group associated with a potential cause of the poor long-term prognosis of MI
• Functional transformations in pericytes
• Both HCM and DCM are the most common clinically observed cardiomyopathies
• Single-cell datasets from both HCM and DCM patients - function of pericytes in each
• Found 20 cell types across these datasets
• Comparing the percentages of different cell types among different disease groups
• Cardiomyocyte I, Fibroblast I, Endothelial I, Macrophage, and Pericyte I
• Top five cell types in each disease group
• Cell types in the number of significant genes
• Signaling by interleukins, neutrophil degranulation, fatty acid metabolism, degradation of the extracellular matrix, and Y-Toxin signaling in the immune system
• Were majorly negatively regulated in all cell types
• Biosynthesis of collagen, modulating enzymes, and collagen formation
• Negatively regulated in the pericytes
• Results indicate that biosynthesis of collagen, modulating enzymes, and collagen formation
• May be the key pathways of pericytes in the pathophysiology of cardiac hypertrophy.
• www.mdpi.com/2227-9059/11/11/2896